Cross-sex hormone therapy raises risk for vascular events in transgender women

1. Transgender women had higher rates of venous thrombotic events (VTE) with cross-sex hormones. 2. Similar rates of ischemic stroke and myocardial infarction were found...

Quality improvement interventions increase adherence to performance measures for stroke in China

1. In this cluster-randomized clinical trial, quality improvement interventions led to slightly greater adherence of evidence-based, performance measures compared to care as usual for...

Family-support intervention does not significantly improve surrogates’ psychological symptoms: The PARTNER trial

1. Family-support intervention delivered by an interprofessional intensive care unit (ICU) team did not significantly reduce anxiety and depression among surrogates of critically ill...

Dupilumab reduces systemic glucocorticoid use in severe asthmatics

1. Glucocorticoid dependent severe asthmatics treated with dupilumab for 24 weeks used significantly lower doses of glucocorticoids while maintaining asthmatic control compared to placebo...

Insulin analogs compared to NPH not associated with reduced hypoglycemia-related hospitalizations

1. In this retrospective cohort study, for patients with type 2 diabetes, initiation of a basal insulin analog compared with NPH insulin was not...

Nearly Half of All Pediatric Buprenorphine Exposures Result in Hospitalization

1. The majority of buprenorphine exposures in children 19 years and younger reported to the National Poison Data System (NPDS) were among children <6...

Drug treatment associated with a significant reduction in death risk following opioid overdose

1. Buprenorphine and methadone maintenance treatment (MMT) was associated with reduced death in opioid users. 2. No significant associations were found between naltrexone and all-cause...

Failures in using personal protective equipment are commonly observed

1. In this qualitative study, active failures in infectious agent transmission precaution practices were observed frequently. 2. Common failures include: failure to enter room with...

Lack of superiority of rivaroxaban for secondary prevention of embolic stroke of undetermined source

1. At a median follow-up of eleven months, rivaroxaban was not superior to aspirin for prevention of secondary stroke after an initial primary embolic...

Restricting perioperative fluid for abdominal surgery patients does not reduce complications: The RELIEF trial

1. Among patients at increased risk for complications undergoing abdominal surgery, those randomized to perioperative fluid restriction did not have increased disability-free survival at...

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