![Metformin treats Fragile X syndrome symptoms in mice [PreClinical]](https://www.2minutemedicine.com/wp-content/uploads/2017/07/Metformin_500mg_Tablets-350x250.jpg)
Metformin treats Fragile X syndrome symptoms in mice [PreClinical]
1. Following treatment with metformin, mouse models of Fragile X syndrome (FXS) demonstrated restored neurological signaling activity and synaptic function....
Combination treatment with calcineurin inhibitors and IL-2 enhances transplant survival [PreClinical]
1. Blood from liver transplant patients treated with a calcineurin inhibitor (CNI) showed increased levels of apoptotic regulatory T cells...
Drug improves cystic fibrosis pulmonary inflammation and protein function [PreClinical]
1. Thymosin α1 (Tα1), an immunomodulatory drug currently in use, decreased lung inflammation in a mouse model of cystic fibrosis...
Low-cost biochip isolates cells for clinical diagnosis [PreClinical]
1. Researchers manufactured a microfluidic biochip, using an inkjet printing system to apply conductive nanoparticles to a polymer substrate. 2....
Lipid nanoparticles deliver messenger RNA for hemophilia B protein replacement therapy [PreClinical]
1. A lipid nanoparticle (LNP) delivery system was developed to introduce factor IX (FIX) messenger RNA (mRNA) into a FIX...
Glucocorticoid compounds improve stem cell transplant efficiency in mice [PreClinical]
1. Following treatment with glucocorticoids, human hematopoietic stem cells (HSCs) from cord blood demonstrated enhanced homing and engraftment to...
Müllerian inhibiting substance is a safe contraceptive that prevents chemotherapy-induced infertility [PreClinical]
1. Müllerian inhibiting substance (MIS) was found to be a successful and safe contraceptive in female mice. 2. Female mice...
Nicotine ameliorates schizophrenia cognitive deficits in mice [PreClinical]
1. A gene alteration in the nicotinic acetylcholine receptor (nAChR) α5 subunit, previously found to be associated with schizophrenia, was...
Augmented adoptive cell transfer eradicates solid tumors [PreClinical]
1. Combining tumor-specific T cells and pathogen-based immune stimulation, reenergized adoptive cell transfer (ReACT) targeted and eradicated tumor cells...
![Engineered stem cells mitigate liver damage caused by radiation [PreClinical]](https://www.2minutemedicine.com/wp-content/uploads/2014/12/Human_embryonic_stem_cells-350x250.png)
Inhibition of the immunoproteasome may improve graft acceptance [PreClinical]
1. A targeted immunoproteasome inhibitor, DPLG3, was found to have high selectivity for the immune cell proteasome and was...