Peripheral perfusion-targeted resuscitation does not lower mortality in septic shock patients
1. In this randomized controlled trial, there was no difference in 28-day mortality in patients with early septic shock between...
Symptomatic and non-symptomatic heart failure associated with increased postoperative mortality in non-cardiac elective surgery
1. In this retrospective cohort study, 90-day postoperative mortality after non-cardiac surgeries was higher for patients with symptomatic or non-symptomatic...
Low free sugar diet reduces hepatic steatosis in nonalcoholic fatty liver disease in adolescent males
1. In this randomized controlled trial, a low free sugar diet resulted in reduced hepatic steatosis compared to a usual...
Fecal microbiota transplantation improves remission rates in ulcerative colitis
1. In this randomized controlled trial, patients who received a donor fecal microbiota transplant (FMT) had a higher rate of...
Low-dose intracoronary alteplase unlikely to improve outcomes in STEMI patients treated with primary PCI
1. In this randomized controlled trial, low-dose intracoronary alteplase given early during primary percutaneous coronary intervention (PCI) for acute ST-Elevation...
Genetic variants of increased waist-to-hip ratios associated with diabetes and coronary disease
1. A polygenic risk score for increased waist-to-hip ratio (WHR) was developed from over 200 risk loci. 2. Polygenic risk...
Vitamin D receptor activators may not reduce cardiovascular risk in patients undergoing hemodialysis.
1. In this randomized clinical trial, patients on hemodialysis who received a vitamin D receptor activator (VDRA) did not have...
Lanadelumab may be an effective prophylactic treatment for hereditary angioedema
1. In this randomized controlled trial, prophylactic lanadelumab reduced attack frequency and severity in patients with hereditary angioedema compared to...
Renin-angiotensin inhibitors may reduce mortality and heart failure readmissions in patients with transcatheter aortic valve replacement
1. In this retrospective cohort study of transcatheter aortic valve replacement (TAVR) patients, Renin-Angiotensin System (RAS) inhibitors administered at hospital...