Small-magnitude differences in risk of adverse events identified between the BNT162b2 and mRNA-1273 across 38 weeks follow-up
1. Among a large cohort of US veterans, the 38-week risks of adverse events were low in both vaccine groups,...
Anti-tau antibody Semorinemab not shown to slow clinical progression of Alzheimer’s disease
1. In this randomized controlled trial, among 457 participants with prodromal to mild Alzheimer’s disease, semorinemab was not shown to...
Screening with digital breast tomosynthesis vs mammography associated with significantly lower risk of advanced breast cancer among women with extremely dense breasts at high risk of breast cancer
1. Compared to mammography, screening with digital breast tomosynthesis was not associated with a significant difference in risk of interval...
Varenicline improves successful smoking cessation amongst African American daily smokers: KIS-IV Trial
1. A double-blinded, randomized controlled trial found that varenicline significantly improved the rate of abstinence from smoking in African American...
Obsessive-compulsive disorder and obsessive-compulsive symptoms associated with an elevated risk of substance misuse
1. Obsessive-compulsive disorder and obsessive-compulsive symptoms were associated with an elevated risk of substance misuse. 2. This association was largely...
Uric acid-lowering therapy not associated with improved kidney function
1. This retrospective cohort study demonstrated an increased risk of developing an estimated glomerular filtration rate (eGFR) less than 60...
Primary hyperparathyroidism associated with an increased risk of fractures and cardiovascular events
1. In this cohort study, among 16 374 Swedish adult patients with primary hyperparathyroidism, the risk hip fracture was increased...
Patients with traumatic intracranial hypertension treated with decompressive craniectomy sustained reduced mortality at 24 months vs standard medical care: RESCUEicp Trial
1. In this randomized clinical trial, patients with intractable intracranial hypertension after traumatic brain injury who received a decompressive craniectomy...
Perioperative dexmedetomidine decreases the incidence of select complications following kidney transplantation
1. This randomized controlled trial found that giving dexmedetomidine for 24 hours at the time of kidney transplant receipt reduced...
Prenatal exposure to antiseizure medication associated with increased risk of autism and intellectual disability
1. In this population-based cohort study, prenatal exposure to topiramate and valproate monotherapy was associated with increased risk of autism...