Collagenase injection is not noninferior to fasciectomy for Dupuytren’s contracture treatment
1. In this randomized controlled trial, among patients with moderate Dupuytren’s contracture, collagenase injection was not found to be noninferior...
Stereotactic body radiotherapy is noninferior to hypofractionated radiotherapy for localized prostate cancer
1. In this randomized controlled trial, among patients with localized prostate cancer, five-fraction stereotactic body radiotherapy (SBRT) was found to...
Beta-blocker interruption not noninferior to continuation following myocardial infarction
1. In this randomized controlled trial, among patients with a history of myocardial infarction (MI), interruption of long-term beta-blocker therapy...
Twice-yearly lenacapavir prevents HIV more effectively than daily F/TDF or F/TAF
1. In this randomized controlled trial, among adolescent girls and young women, it was found that twice-yearly lenacapavir resulted in...
Tulisokibart effectively induces clinical remission in moderately to severely active ulcerative colitis
1. In this randomized controlled trial, among patients with moderately to severely active ulcerative colitis, tulisokibart, a monoclonal antibody directed...
Oxygen therapy for 15 versus 24 hours per day does not change hypoxemia-related mortality
1. In this randomized controlled trial, among patients with severe hypoxemia, long-term oxygen therapy used for 24 hours per day...
Plozasiran reduces triglyceride levels in mixed hyperlipidemia
1. In this randomized controlled trial, among patients with mixed hyperlipidemia, plozasiran significantly reduced fasting triglyceride levels compared with placebo....
Adjunctive treatment with argatroban or eptifibatide does not improve post-stroke functional outcomes
1. In this randomized controlled trial, among ischemic stroke patients treated with intravenous thrombolysis, it was found that adjunctive intravenous...
Liberal transfusion strategy does not improve post-traumatic brain injury neurologic outcomes
1. In this randomized controlled trial, among traumatic brain injury (TBI) patients with anemia, a liberal red-cell transfusion strategy resulted...