Triplet therapy of telmisartan, amlodipine, and indapamide shows superior blood pressure control in hypertension management
1. Mean reduction in home systolic blood pressure at 12 weeks was greater with GMRx2 than with dual combination therapy....
Nivolumab does not improve survival in patients with advanced renal cell carcinoma with progression after immune checkpoint inhibitors
1. No significant difference was seen regarding progression-free survival between the tivozanib-nivolumab and tivozanib monotherapy groups. 2. Serious adverse events...
Pembrolizumab with chemoradiotherapy improves survival in locally advanced cervical cancer
1. 36-month overall survival was significantly greater in the pembrolizumab-chemoradiotherapy group compared to placebo-chemoradiotherapy. 2. Grade 3 or higher adverse...
Mineralocorticoid receptor antagonists reduce hospitalizations in patients with heart failure with preserved or mildly reduced ejection fraction
1. Cardiovascular death and first heart failure hospitalization was reduced among HFrEF patients compared to HFmrEF and HFpEF patients. 2....
Perioperative pembrolizumab improves survival in resectable early-stage non-small cell lung cancer
1. 36-month overall survival and median event-free survival were significantly greater in the pembrolizumab group compared to control. 2. Grade...
Weekly insulin efsitora alfa is non-inferior to daily insulin degludec for reducing HbA1c in type 1 diabetes
1. Once weekly efsitora demonstrated non-inferiority compared with degludec with regards to change in HbA1c. 2. Patients in the efsitora...
Liver transplantation plus chemotherapy improves survival in patients with unresectable colorectal liver metastases
1. 5-year survival was significantly greater in the liver transplantation plus chemotherapy group compared to chemotherapy alone. 2. Serious adverse...
Active mechanical circulatory support does not reduce mortality in acute myocardial infarction-related cardiogenic shock
1. Early use of mechanical circulatory support did not reduce 6-month all-cause mortality. 2. MCS was associated with increased major...
Optical coherence tomography-guided angioplasty reduces adverse events compared to angiography guidance
1. Major cardiac events were significantly lower in the OCT-guided group compared to the angiography-guided group. 2. Stroke, bleeding events,...
Ticagrelor monotherapy reduces bleeding risk compared to dual antiplatelet therapy for patients following coronary stenting
1. Ticagrelor was non-inferior to DAPT for the incidence of major adverse cardiovascular and cerebrovascular events. 2. Ticagrelor monotherapy significantly...
