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2 Minute Medicine Rewind March 8, 2021

...pital admission related to bleeding, and a prescription for an OAC within 100 days prior to admission. Of the 6793 patients in the study, 70.5% of patients resumed using an OAC within a year of admission (71.6% for GI bleed, and 45.6% for intracranial hemorrhage). For all categories of bleed, there was a lower rate of thrombosis for those who resumed OACs (10.0% vs 14.9%, adjusted hazards ratio 0.60, 95% CI 0.50-0.72). However, the rates of bleedi...

2 Minute Medicine Rewind July 27, 2020

...over the years, increasing six-fold in the United States between 1975 and 2001. Currently, Barrett’s Esophagus (BE) is the sole known lesion to be a precursor for EAC, and factors such as for obesity, use of tobacco, and gastroesophageal reflux disease (GERD) have been identified as associated risk factors. Currently however, the association between tonsillectomy and development of EAC is not well characterized, despite these procedures being rela...

2 Minute Medicine Rewind November 16, 2020

...k follow-up: T-score -5.7, 95% CI -14.4 to 2.9 for intervention; T-score -2.0, 95% CI -4.0 to 0.1 for control; p = 0.22). There were also no differences found for coping, health symptoms, patient satisfaction, and shared decision-making. However, the intervention group received specialist palliative care more frequently (37% versus 27%, p = 0.002) and had more advanced directives included in medical files (10% versus 3%, p < 0.001). In conclusion,...

2 Minute Medicine Rewind January 11, 2021

...19–214.37, absolute risk 27.6%) and respiratory failure (OR 11.36, 95% CI 10.74–12.02, absolute risk 22.6%), in addition to other common conditions such as acute kidney failure (OR 3.50, 95% CI 3.34–3.68, absolute risk 11.8%) and sepsis (OR 4.23, 95% CI 4.01–4.46, absolute risk 10.4%). Conditions that had high association with COVID-19 diagnosis but low absolute risk included myocarditis, pneumothorax, and disseminated intravascular coagulation (a...

2 Minute Medicine Rewind August 23, 2021

...ion consisted of 384,130 adults with 842,394 medical records from between 2001 and 2016. Imaging from satellites was used to estimate PM2.5 exposure based on home addresses of the participants, grouping them into low, moderate, and high exposure categories (<22.4, 22.4-26.0, and >26.0 ug/m3 respectively). Surveys were used to measure level of physical exercise, and participants were grouped into inactive, moderate, and high exercise categories. As...

2 Minute Medicine Rewind August 24, 2020

...n children of parents with high income and high educational attainment (HR 0.85, 95% Ci 0.81-0.89; HR 0.72, 95% CI 0.69-0.75 respectively). In terms of air pollution, exposure to particulate matter less than 2.5 um in a diameter was the only factor to be positively associated with asthma and persistent wheezing across all models. For every increase in pollutant concentration by 5 ug/m 3 , the HR was 1.05 (95% CI, 1.03-1.07). Study findings reinfor...

2 Minute Medicine Rewind August 17, 2020

...utcomes. Multivariable regression analyses were used and iodine intake of 100 ug per day was used as reference (aOR=1.0) as intakes of 100-150 ug/d were usually associated with the least adverse outcomes. Of non-supplement users, 75 ug iodine intake per day pregnancies were associated with higher risk of preeclampsia (aOR 1.14, 95% CI 1.08-1.22), preterm delivery <37 weeks (aOR 1.10, 95% CI 1.04-1.16), and reduced fetal growth z-scores (-0.08 SD,...

2 Minute Medicine Rewind May 24, 2021

...erized by statistically younger age (mean age [SD] = 48.9 [8.1] vs. 52.3 [10.4], p = 0.040). Additionally, patients with an AKI had a lower pre-operative eGFR (mean eGFR [SD] = 63.5 [23.5] vs. 76.8 [21.4], p < 0.001). The study found that AKI was associated with higher extracorporeal circulation (ECC) and cross-clamp times (p = 0.036 and p = 0.053, respectively). After the operation, a higher percentage of patients in the AKI group required a bloo...

2 Minute Medicine Rewind October 5, 2020

...ribed to patients with nephrolithiasis for pain control; in fact, between 2007 and 2014, opioid use among individuals with a history of nephrolithiasis was significantly higher compared with those without. This retrospective cohort study examined 135 patients with symptomatic nephrolithiasis managed with either trial of passage (TOP) with medical expulsion therapy (MET) or with surgical intervention, consisting of either primary ureteroscopy (n =...

2 Minute Medicine Rewind August 10, 2020

...ns in occasional-to-daily anti-reflux medication usage (63.1% vs 13.8%, OR 0.094, 95% CI 0.054 to 0.161) and symptoms of dysphagia (11.2% vs. 2.8%, OR 0.224, 95% CI 0.076 to 0.652). Overall, this study suggested that robotic repair of PEHs is a safe, well-tolerated procedure with low rates of recurrence, results in a positive lifestyle impact among patients, and may represent a viable alternative to laparoscopic repair.   Afabicin, a first-in-clas...

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