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Quick Take: Short-term androgen suppression and radiotherapy versus intermediate-term androgen suppression and radiotherapy, with...

...difference in prostate cancer-specific mortality between the no zoledronic acid and zoledronic acid groups (11.7% vs. 11.2%, respectively, sHR 0.95, 95% CI 0.69 to 1.32, p=0.78). There were twelve serious drug-related adverse events. A major limitation of this study was the change in the primary endpoint in 2011 from prostate-specific antigen (PSA) progression to prostate cancer-specific mortality, which compromised the power of the study. Overall...

Patient Basics: Esophagitis

...ause esophagitis. Treatment Treatment depends on the cause of esophagitis. Acid reflux — Acid blocking medications, including H2-blockers and proton-pump inhibitors, may be used. For a few difficult cases, a type of stomach surgery can also help prevent reflux. Medications — Drinking a full glass of water after taking a pill can help. Usually, if esophagitis has occurred, it is necessary for you to stop the medicine at least temporarily while you...

Blood cell folate concentration may accurately predict neural tube defects

...early pregnancy. The second study was a randomized clinical trial of folic acid supplementation in 2003-05 in which 1,194 Chinese women were assigned to different dosages of folic acid (100-4000μg/day). Red blood cell folate concentration data from the randomized clinical trial was used to estimate RBC folate concentration levels for participants in the first trial based on their reported pill consumption. A Bayesian model was applied and a dose-r...

Patient Basics: Gastroesophageal Reflux Disease (GERD)

...medications that can be used to treat GERD. They include: Over-the-counter acid buffers — Buffers neutralize acid. They include Mylanta, Maalox, Tums, Rolaids, and Gaviscon. The liquid forms of these medications work faster But the tablets may be more convenient. Antacids that contain magnesium can cause diarrhea. And antacids that contain aluminum can cause constipation. Your doctor may advise you to alternate antacids to avoid these problems. Th...

Quick Take: Ursodeoxycholic acid versus placebo in women with intrahepatic cholestasis of pregnancy (PITCHES)

...epatic cholestasis of pregnancy were randomized to receive ursodeoxycholic acid or placebo to evaluate whether ursodeoxycholic acid reduces adverse perinatal outcomes in this patient population. The primary outcome was a composite of perinatal death (in-utero fetal death after randomization or death up to 7 days after birth), preterm delivery, or neonatal unit admission for at least 4 hours after birth up to hospital discharge. Researchers found t...

#VisualAbstract: Ursodeoxycholic acid versus placebo in women with intrahepatic cholestasis of pregnancy (PITCHES)

...epatic cholestasis of pregnancy were randomized to receive ursodeoxycholic acid or placebo to evaluate whether ursodeoxycholic acid reduces adverse perinatal outcomes in this patient population. The primary outcome was a composite of perinatal death (in-utero fetal death after randomization or death up to 7 days after birth), preterm delivery, or neonatal unit admission for at least 4 hours after birth up to hospital discharge. Researchers found t...

#VisualAbstract: Safety-Net Hospitals, Neighborhood Disadvantage, and Readmissions Under Maryland’s All-Payer Program

...er association observed between readmission risk and the hospital’s safety-net index compared to the patient’s neighborhood disadvantage status. Evidence Rating Level: 2 (Good) Study Rundown: The term safety-net hospital refers to a center that cares for a large number of significantly disadvantaged patients. The authors of this study evaluated the independent contributions of patients’ neighborhoods and the hospital’s service area with respect to...

2 Minute Medicine Rewind October 12, 2020

...group) and was conducted at four level 1 trauma centres in the US, between 2015 and 2019. The mean ±SD age was 42±18 years, and 74% were male. Overall, the study found no significant difference in 30-day mortality, with 36 deaths in the intervention and 45 deaths in the placebo (hazard ratio 0.81, 95% CI 0.59 to 1.11, p = 0.18). With regards to safety, there was no difference in arterial thrombotic complications and myocardial infarction, althoug...

Folic acid and zinc supplementation in men not associated with increased fertility

...lity care centers across the US (Utah, Illinois and Minnesota) between June 2013 and December 2017. The study was fully completed in April 2019, with a total of 2370 men age 18 and above and women aged 18-45 being consented into the study if they were seeking infertility treatment. Couples were excluded if using a donor sperm or gestational surrogate, pregnant at time of enrollment, and/or if male partner was diagnosed with obstructive azoospermia...

2 Minute Medicine Rewind September 21, 2020

...use of its role in antioxidation and neuroprotection. Hyperuricemia affects 20% of people worldwide, and is related to conditions such as gout, chronic kidney disease, and cardiovascular disease, as well as early mortality. However, low uric acid is also related to diseases such as Alzheimer’s and Parkinson’s. Both sleep quality and duration are thought to influence uric acid levels, but previous literature has not studied this association with bo...

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