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Sodium-glucose cotransporter 2 inhibitors associated with reduced mortality compared with sulfonylureas in patients with...

...associated with reduced risk of all-cause mortality (HR, 0.81; 95%CI, 0.75-0.87) compared to sulfonylureas, with an event rate difference of -5.15 (95%CI, -7.16 to -3.02) deaths per 1,000 person-years. SGLT2 inhibitors were also associated with a reduced risk of mortality regardless of cardiovascular disease status, estimated glomerular filtration rate category and albuminuria status. In per-protocol analyses, long-term use of SGLT2 inhibitors wa...

Wellness Check: Mental Health

...come data to establish pretrial performance were included. Patients aged 18-70 years old who presented during the trial period and made their own mental health care decisions were included. Adult outpatients were recruited from mental health centers in Ohio and were excluded if they were unable to consent without a delegated decision maker. The primary outcomes were improvement across Treatment Outpatient Package (TOP) domains and distress (measur...

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Social media interventions may improve physical activity and mental wellness

...being. Inclusion criteria were randomized control trials, controlled before-and-after studies, and interrupted time series which used an interactive online intervention to improve health behaviours in adults. Studies were excluded if the program that was evaluated had no social component. Study outcomes included physical health, mental health, adverse outcomes, and sub-group analysis to assess health equity. A total of 88 studies were included in...

2 Minute Medicine Rewind July 6, 2020

...ls of ELCE were associated with lower global AD pathology scores (estimate -0.057, standard error [SE] 0.022, p = 0.01), amyloid-β (estimate -0.136, SE 0.066, p = 0.04), and tau (estimate -0.188, SE, 0.076, p = 0.01). Comparisons of ELCE and age at death estimates were utilized to contextualize effect size (estimate 0.007, SE 0.002, p = 0.003). Specifically, a one-unit increase in ELCE equated to an effect size associated with being eight years yo...

Adolescent behaviours toward COVID-19 driven by perception of disease severity

....22) and disinfecting (β = 0.24, 0.17 to 0.32) but decreased hoarding (β = -0.07, 95% CI -0.14 to -0.01). Greater social trust was associated with less hoarding (β = -0.09, 95% CI -0.16 to -0.02) while higher self-interest values were associated with greater hoarding (β = 0.008, 95% CI 0.01 to 0.15) and less social distancing (β = 0.08, -0.15 to -0.01). Study findings emphasize the importance of portraying public health crises appropriately as the...

Pain and sleep may have a bidirectional causal relationship

...athered from a British biobank and 23andMe, in which the diagnosis was self-reported. Two-sample Mendelian randomization analysis provided clarity as to which SNPs were significant for pain and insomnia, while further Mendelian randomization analysis allowed to correlate insomnia and pain symptoms with genetic data. This study showed a bidirectional relationship between insomnia and pain. Symptoms of insomnia acted as a risk factor for developing...

Association between BMI and diabetes risk among low-middle income countries varies considerably by geographical...

...completed, a search was done for a suitable comparable survey done after 2008 with a 50% or higher response rate. In total, there were 58 surveys analyzed (9 non-STEPS) from 57 LMICs. Diabetes was defined as fasting plasma glucose > 7.0 mmol/L, random plasma glucose > 11.1 mmol/L, or a HbA1C > 6.5%. If no values were available, then the use of a diabetes medication was sufficient. The most used measurement to confirm diabetes was POC fasting gluc...

Wellness Check: Mental Health

...ceding their ED visit. Patients who were male, from a rural community (<10,000 residents), immigrants, not followed by a primary care physician, and who presented with substance use disorder were more likely to present without 2-year history of outpatient care. One limitation of this study was that there were no controls for external mental health programs that patients could have accessed previously, such as privately funded programs or utilizati...

Analysis of the short and long-term in-hospital complications following diagnosis of COVID-19

...se 2019 in China In-depth [prospective cohort]: Between Jan 17 and Aug 4, 2020, 80 388 patients were enrolled from 302 clinical sites in the UK. Included patients were adults ≥19 years old with suspected or laboratory confirmed COVID-19. Those with duplicate patient records and no in-hospital complication were excluded. Overall, 36 367 patients (49.7%) had ≥1 in-hospital complication and were included in the final analysis. Among enrolled patients...

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