• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • Write for us
  • Contact us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Oncology

Safety, Tolerability, and Potential Clinical Activity of a Glucocorticoid-Induced TNF Receptor–Related Protein Agonist Alone or in Combination With Nivolumab for Patients With Advanced Solid Tumors

byDonna LeetandArnav Agarwal, MD
November 19, 2019
in Oncology
Reading Time: 2 mins read
0
Share on FacebookShare on Twitter

RELATED REPORTS

Neoadjuvant nivolumab with chemotherapy increases survival in resectable non-small-cell lung cancer

Neoadjuvant nivolumab improves survival in patients with resectable non-small cell lung cancer

#VisualAbstract: Neoadjuvant nivolumab plus chemotherapy increases event-free survival in resectable non-small-cell lung cancer

1. The glucocorticoid-induced TNF receptor-related protein agonist, BMS-986156, is safe and tolerable as monotherapy and in combination with nivolumab.

Evidence Rating Level: 2 (Good)

Although immune checkpoint inhibitors (ICI) have shown clinical efficacy in a wide variety of cancers, a significant portion remain unresponsive to checkpoint blockade. Therefore, new strategies for modulating the critical balance of T-cell activation and antigen tolerance are needed. Agonistic antibodies targeting the glucocorticoid-induced TNF receptor-related protein (GITR) have been hypothesized to synergize with and augment the effect of ICIs. The GITR-agonist BMS-986156 was engineered to increase T-cell activation and deplete intratumoral regulatory T cells. In this open-label, non-randomized, phase I/IIa study, 292 patients with advanced solid tumors and an Eastern Cooperative Oncology Group (ECOG) performance status of 1 or less were assigned to either BMS-986156 as monotherapy at varying doses (10, 30, 100, 240, or 800 mg), or in combination with 240mg of nivolumab every 2 weeks. One cohort also received 480 mg of BMS-986156 plus 480 mg of nivolumab every 4 weeks. The primary endpoints were safety, tolerability, and dose-limiting toxic effects. Key secondary endpoints included antitumor activity and exploratory biomarker analyses. The monotherapy cohort included 34 patients (4 patients completed initial treatment), and the BMS-986156 cohort included 258 patients (65 patients completed initial treatment). Baseline characteristics were similar between the monotherapy and combination therapy cohorts. Researchers found that the safety profile of BMS-986156 was tolerable; no grade 3 to 5 treatment-related adverse events occurred with BMS-986156 monotherapy; grade 3 to 4 treatment-related adverse events occurred in 24 patients (9.3%) receiving BMS-986156 plus nivolumab, with no grade 5 treatment-related adverse events. There was a trend towards an increase in CD8+ T-cell and natural killer cell proliferation after administration of both BMS-986156 monotherapy and combination therapy, although these results were not statistically significant. No clinical responses were seen with BMS-986156 monotherapy, and objective response rates ranged from 0% to 11.1% across combination therapy cohorts, similar to historically observed objective response rates with anti-PD-1 therapy alone. This study was limited by the lack of comparator groups, such as a nivolumab monotherapy group; therefore, the contribution of the GITR agonist to the clinical activity of the combination therapy remains unclear. Overall, this study highlights the safety and tolerability of the GITR agonistic antibody BMS-986156 with or without nivolumab, but further studies with comparator groups are warranted to determine if this therapy is an effective strategy in a broad patient population.

Click to read the study in JAMA Oncology

Image: PD

©2019 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

Tags: BMS-986156glucocorticoid-induced TNF receptor-related protein (GITR)immune checkpoint inhibitors (ICI)Nivolumab
Previous Post

Developmental assessment at 9 months of age can predict fetal alcohol syndrome

Next Post

Communication With Older Patients With Cancer Using Geriatric Assessment

RelatedReports

Surgical site anesthetic infusion may enhance analgesia after mastectomy
Oncology

Neoadjuvant nivolumab with chemotherapy increases survival in resectable non-small-cell lung cancer

May 30, 2022
Dacomitinib may be effective in EGFR-associated lung cancer
Chronic Disease

Neoadjuvant nivolumab improves survival in patients with resectable non-small cell lung cancer

May 9, 2022
#VisualAbstract: Neoadjuvant nivolumab plus chemotherapy increases event-free survival in resectable non-small-cell lung cancer
StudyGraphics

#VisualAbstract: Neoadjuvant nivolumab plus chemotherapy increases event-free survival in resectable non-small-cell lung cancer

April 28, 2022
Oncology

Neoadjuvant nivolumab plus chemotherapy increases event-free survival in resectable non-small-cell lung cancer

April 18, 2022
Next Post
Quick Take: The burden of health conditions for middle-aged and older adults in the United States: disability-adjusted life years

Communication With Older Patients With Cancer Using Geriatric Assessment

#VisualAbstract: Effect of continued folic acid supplementation beyond the first trimester of pregnancy on cognitive performance in the child

#VisualAbstract: Effect of continued folic acid supplementation beyond the first trimester of pregnancy on cognitive performance in the child

Adolescents with mental health problems at higher risk for e-cigarette use

Clinical presentation, treatment, and short-term outcomes of lung injury associated with e-cigarettes or vaping

License Our Award-Winning Physician-Written Medical News and Visual Abstracts

2 Minute Medicine is the leading authoritative medical news licensing service, and the only with reports written by practicing doctors.

LICENSE CONTENT

2MM+ Premium Access

No ads & unlimited access to all current reports, over 9000 searchable archived reports, visual abstracts, Weekly Rewinds, and the online edition of The Classics Series™ textbook.

Subscription Options
2 Minute Medicine

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Vitamin and mineral supplementation associated with minimal to no benefit in the primary preventing of cardiovascular disease and cancer – US Preventative Services Task Force
  • RSVpreF vaccine prevents symptomatic respiratory syncytial virus infection
  • Incidence of Kawasaki disease found to be lower during the COVID-19 pandemic in the United States
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.