Tag: aspirin

In this section, we highlight the key high-impact studies, updates, and analyses published in medicine during the past week. Cytisine versus Nicotine for Smoking Cessation When compared with placebo, cytisine, a partial nicotinic acetylcholine receptor agonist, has been shown to nearly double the chance of smoking cessation at 6 months. This...
1. Alternate day aspirin therapy was associated with neither net health benefit nor detriment for CVD and cancer in the majority of women in light of increased risk of gastrointestinal bleed. 2. However, the number needed to treat to avoid one cardiovascular event was 29 in women greater than 65...
1. Aspirin use pre- or post-diagnosis of prostate cancer was not significant associated with a decrease in prostate-cancer specific survival. 2. Post-diagnosis daily aspirin use may be associated with increased survival in patients with high-risk prostate cancer. Evidence Rating Level: 3 (Satisfactory) Study Rundown: Several observational studies have suggested that aspirin use...
1. Use of low-dose aspirin was associated with a reduced risk for preeclampsia, intrauterine growth restriction and preterm birth in women at high risk for preeclampsia. 2. Low-dose aspirin was not associated with any appreciable harms during pregnancy. Evidence Rating Level: 1 (Excellent) Study Rundown: Preeclampsia is among the leading causes of...
Image: PD  1. Among patients with venous thromboembolism, clinically relevant bleeding and major bleeding increased with concomitant anticoagulant and NSAID use.   2. Concomitant Aspirin use also increased risk of major bleeding and clinically relevant bleeding. Evidence Rating Level: 2 (Good)  Study Rundown:  Anticoagulation is the standard of care for the treatment of...
Image: PD  1. From a systematic review, the U.S. Preventative Services Task Force (USPSTF) has determined that aspirin use decreases the risk of preeclampsia, intrauterine growth restriction, and preterm birth.  Evidence Rating Level: 1 (Excellent) Study Rundown: One of the leading causes of maternal death globally is preeclampsia, and since the only...
Image: PD In this section, we will highlight the key high-impact studies, updates, and analyses published in medicine during the past week. Health Care–Associated Infection After Red Blood Cell Transfusion A Systematic Review and Meta-analysis Direct transmission of infectious agents via RBC transfusion is extremely low in developed countries; however, RBC transfusions trigger...
Image: CC/Wiki  1. Perioperative Aspirin use did not correlate with reduction of death or nonfatal myocardial infarction within 30 days post-operatively.  2. Perioperative Aspirin use increased risk of major bleeding.  3. Aspirin use did not affect the median length of hospital stay.  Evidence Rating Level: 1 (Excellent)  Study Rundown: This study sought to determine...
Classics Series, Landmark Trials in Medicine
Image: PD 1. Children with Kawasaki disease treated with a combined regimen of aspirin and intravenous gamma globulin had significantly lower rates of coronary artery aneurysms when compared to those receiving aspirin only. 2. Children treated with the combined regimen had significantly shorter fevers and a greater decrease in inflammatory markers...
Image: PD 1. There was no difference between warfarin and aspirin in preventing recurrent stroke in patients with significant atherosclerotic intracranial stenosis. 2. Warfarin was associated with a significantly higher incidence of major hemorrhage compared to the aspirin group. Original Date of Publication: March 31, 2005 Study Rundown: This trial randomized patients who...