Tag: lung cancer

1. Although lung cancer screening gave patients the opportunity to reevaluate their health, routine screening may also lower a patient’s motivation for smoking cessation. 2. A concerning misperception amongst smokers is the belief that undergoing imaging testing yields the same benefits as smoking cessation. Evidence Rating Level: 3 (Fair) Study Rundown: The...
Nivolumab versus Docetaxel in Advanced Squamous-Cell Non–Small-Cell Lung Cancer Cancer immunotherapy seeks to up regulate immune activators and down regulate immune suppressing agents to induce the body's own immune system to confront malignancy. Nivolumab, a monoclonal antibody to PD1 (immune checkpoint inhibitor), has been tried in highly immunogenic malignancies such...
1. Radiofrequency ablation with a multiple-electrode switching system can safely be used to successfully treat lung tumors 2-5 cm in size in nonsurgical candidates. Evidence Rating Level: 4 (Below-Average) Study Rundown: Patients with non-surgical lung tumors face limited treatment options, many of which are often accompanied by a high risk...
1. An electronic health record-based trigger algorithm was developed to identify patients with chest imaging results suspicious for malignancy at risk for delayed diagnosis of lung cancer due to a lack of timely follow-up, providing a potential semi-automated method to prevent delayed or overlooked care. 2. The trigger algorithm showed...
In this section, we highlight the key high-impact studies, updates, and analyses published in medicine during the past week. Effect of a Retrievable Inferior Vena Cava Filter Plus Anticoagulation vs Anticoagulation Alone on Risk of Recurrent Pulmonary Embolism The placement of inferior vena cava (IVC) filters as an adjunct to anticoagulation...
1. In patients with T790M EGFR-mutated treatment-resistant lung cancer who were treated with rociletinib, there was an objective response rate of 59%, compared to only 29% in T790M-negative disease. 2. The most common adverse effect noted in patients treated with rociletinib was hyperglycemia, which was responsive to dose de-escalation...
1. When applied to the original NLST cohort, Lung-RADS lung cancer screening criteria had a lower false positive rate, a higher positive predictive value and a lower sensitivity, compared to the NLST criteria.  Evidence Rating Level: 2 (Good) Study Rundown: The National Lung Screening Trial (NLST) criteria for lung...
1. Among patients with non-small-cell lung cancer (NSCLC) and ALK gene rearrangements, treatment with oral crizotinib therapy was superior to standard intravenous chemotherapy in terms of progression-free survival and objective response rate, but not overall mortality. 2. Crizotinib was associated with side effects including vision disorders, diarrhea, and edema,...
Originally published by Harvard Health. What Is It? One of the most common cancers, lung cancer usually occurs when a cancer-causing agent, or carcinogen, triggers the growth of abnormal cells in the lung. These cells multiply out of control and eventually form a tumor. As the tumor grows, it can block or...
In this section, we highlight the key high-impact studies, updates, and analyses published in medicine during the past week. Cost-Effectiveness of CT Screening in the National Lung Screening Trial The National Lung Screening Trial, a randomized controlled trial, demonstrated that lung cancer screening with low-dose computed tomography (CT) resulted in decreased...