Tag: lung cancer

1. Among patients with known lung cancer, evidence of malignancy was frequently present but undiagnosed on prior chest computed tomography (CT) scans obtained for the purposes of lung cancer screening. 2. In the present study, all malignant lung nodules that were visible on prior scans represented early, stage I tumors,...
1. The specificity of FDG-PET imaging for diagnosing lung cancer is significantly reduced in areas endemic to infectious lung diseases. 2. The sensitivity of FDG-PET imaging did not significantly change when studied in areas endemic to infectious lung diseases. Evidence Rating Level: 3 (Average) Study Rundown: Currently, positron emission tomography (PET) combined...
1. The addition of thoracic radiotherapy in patients receiving prophylactic cranial irradiation and chemotherapy was shown to significantly increase overall survival at two years in patients with extensive-stage small cell lung cancer (ES-SCLC). 2. Disease progression was less likely in patients receiving thoracic radiotherapy in addition to prophylactic cranial...
1. The prevalence of major depression was highest in those with lung cancer, followed by gynecological, breast, colorectal, and genitourinary cancers. 2. Most of the cancer patients studied (73%) did not receive effective treatment for their depression. Evidence Rating Level: 3 (Average) Study Rundown: Major depression is commonly seen in patients with...
1. Treatment of depression in patients with lung cancer using a collaborative care model resulted in significantly lower depression severity ratings than in patients treated using usual care by their primary care physician.  2. Lung cancer patients treated with a collaborative care model also reported improvements in self-rated depression, anxiety,...
1. In a microarray analysis of excised lung tumor specimens, 12 miRNAs were found to be associated with response to platinum-based chemotherapy. 2. From these 12 miRNAs, a three-miRNA panel could accurately predict patients’ response to platinum-based chemotherapy, irrespective of differences in oncogene expression and clinical characteristics. Study Rundown: Adenocarcinoma of...
1. Brachytherapy following sublobar resection (BSR) had no significant association with local NSCLC recurrence compared to sublobar resection (SR) alone. 2. Three-year overall survival rates were similar between BSR and SR. Evidence rating level: 1 (Excellent) Study Rundown: Compared to lobectomy, sublobar resection for non-small-cell lung cancer (NSCLC) is associated with greater...
 Image: PD  1. Oncogenic drivers were identified in 64% of lung adenocarcinomas.  2. Median survival was longer in patients treated with therapies targeted at the oncogenic drivers.  Evidence Rating Level: 2 (Good)  Study Rundown: Lung adenocarcinoma is the most common type of lung cancer diagnosed in the United States. Over half of these...
Image: PD 1. Pleural effusions were associated with worse survival in non-small-cell lung cancer (NSCLC), particularly when they arose in early stage disease. Evidence rating level: 2 (Good) Study Rundown: Malignant pleural effusion containing malignant cells helps to define metastatic staging of lung cancer; however, diagnostic thoracentesis and pleural biopsy are not...
 Image: PD 1. Compared to men, women who smoked between 1-14 cigarettes per day were at higher risk of developing negative complications. 2. Differences in risk between men and women disappeared as smoking exposure increased. Evidence Rating Level: 2 (Good) Study Rundown: This study investigated differences in the effects of smoking exposure in...