Tag: open label

$Phase II O-12-M1: Melflufen plus dexamethasone showed benefits in long-term survival outcomes in relapsed/refractory multiple myeloma$

Phase II O-12-M1: Melflufen plus dexamethasone showed benefits in long-term survival outcomes in relapsed/refractory multiple myeloma

byKathleen Lau

February 5, 2021

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

No Result

View All Result

img:is([sizes=auto i],[sizes^="auto," i]){contain-intrinsic-size:3000px 1500px}img.wp-smiley,img.emoji{display:inline !important;border:none !important;box-shadow:none !important;height:1em !important;width:1em !important;margin:0 .07em !important;vertical-align:-.1em !important;background:none !important;padding:0 !important}:root{--wp-block-synced-color:#7a00df;--wp-block-synced-color--rgb:122,0,223;--wp-bound-block-color:var(--wp-block-synced-color);--wp-editor-canvas-background:#ddd;--wp-admin-theme-color:#007cba;--wp-admin-theme-color--rgb:0,124,186;--wp-admin-theme-color-darker-10:#006ba1;--wp-admin-theme-color-darker-10--rgb:0,107,160.5;--wp-admin-theme-color-darker-20:#005a87;--wp-admin-theme-color-darker-20--rgb:0,90,135;--wp-admin-border-width-focus:2px}@media (min-resolution:192dpi){:root{--wp-admin-border-width-focus:1.5px}}.wp-element-button{cursor:pointer}:root .has-very-light-gray-background-color{background-color:#eee}:root .has-very-dark-gray-background-color{background-color:#313131}:root .has-very-light-gray-color{color:#eee}:root .has-very-dark-gray-color{color:#313131}:root .has-vivid-green-cyan-to-vivid-cyan-blue-gradient-background{background:linear-gradient(135deg,#00d084,#0693e3)}:root .has-purple-crush-gradient-background{background:linear-gradient(135deg,#34e2e4,#4721fb 50%,#ab1dfe)}:root .has-hazy-dawn-gradient-background{background:linear-gradient(135deg,#faaca8,#dad0ec)}:root .has-subdued-olive-gradient-background{background:linear-gradient(135deg,#fafae1,#67a671)}:root .has-atomic-cream-gradient-background{background:linear-gradient(135deg,#fdd79a,#004a59)}:root .has-nightshade-gradient-background{background:linear-gradient(135deg,#330968,#31cdcf)}:root .has-midnight-gradient-background{background:linear-gradient(135deg,#020381,#2874fc)}:root{--wp--preset--font-size--normal:16px;--wp--preset--font-size--huge:42px}.has-regular-font-size{font-size:1em}.has-larger-font-size{font-size:2.625em}.has-normal-font-size{font-size:var(--wp--preset--font-size--normal)}.has-huge-font-size{font-size:var(--wp--preset--font-size--huge)}:root .has-text-align-center{text-align:center}:root .has-text-align-left{text-align:left}:root .has-text-align-right{text-align:right}.has-fit-text{white-space:nowrap !important}#end-resizable-editor-section{display:none}.aligncenter{clear:both}.items-justified-left{justify-content:flex-start}.items-justified-center{justify-content:center}.items-justified-right{justify-content:flex-end}.items-justified-space-between{justify-content:space-between}.screen-reader-text{word-wrap:normal !important;border:0;clip-path:inset(50%);height:1px;margin:-1px;overflow:hidden;padding:0;position:absolute;width:1px}.screen-reader-text:focus{background-color:#ddd;clip-path:none;color:#444;display:block;font-size:1em;height:auto;left:5px;line-height:normal;padding:15px 23px 14px;text-decoration:none;top:5px;width:auto;z-index:100000}html :where(.has-border-color){border-style:solid}html :where([style*=border-color]){border-style:solid}html :where([style*=border-top-color]){border-top-style:solid}html :where([style*=border-right-color]){border-right-style:solid}html :where([style*=border-bottom-color]){border-bottom-style:solid}html :where([style*=border-left-color]){border-left-style:solid}html :where([style*=border-width]){border-style:solid}html :where([style*=border-top-width]){border-top-style:solid}html :where([style*=border-right-width]){border-right-style:solid}html :where([style*=border-bottom-width]){border-bottom-style:solid}html :where([style*=border-left-width]){border-left-style:solid}html :where(img[class*=wp-image-]){height:auto;max-width:100%}:where(figure){margin:0 0 1em}html :where(.is-position-sticky){--wp-admin--admin-bar--position-offset:var(--wp-admin--admin-bar--height,0px)}@media screen and (max-width:600px){html :where(.is-position-sticky){--wp-admin--admin-bar--position-offset:0px}}.wp-block-button__link{color:#fff;background-color:#32373c;border-radius:9999px;box-shadow:none;text-decoration:none;padding:calc(.667em + 2px) calc(1.333em + 2px);font-size:1.125em}.wp-block-file__button{background:#32373c;color:#fff;text-decoration:none}:root{--wp--preset--aspect-ratio--square:1;--wp--preset--aspect-ratio--4-3:4/3;--wp--preset--aspect-ratio--3-4:3/4;--wp--preset--aspect-ratio--3-2:3/2;--wp--preset--aspect-ratio--2-3:2/3;--wp--preset--aspect-ratio--16-9:16/9;--wp--preset--aspect-ratio--9-16:9/16;--wp--preset--color--black:#000;--wp--preset--color--cyan-bluish-gray:#abb8c3;--wp--preset--color--white:#fff;--wp--preset--color--pale-pink:#f78da7;--wp--preset--color--vivid-red:#cf2e2e;--wp--preset--color--luminous-vivid-orange:#ff6900;--wp--preset--color--luminous-vivid-amber:#fcb900;--wp--preset--color--light-green-cyan:#7bdcb5;--wp--preset--color--vivid-green-cyan:#00d084;--wp--preset--color--pale-cyan-blue:#8ed1fc;--wp--preset--color--vivid-cyan-blue:#0693e3;--wp--preset--color--vivid-purple:#9b51e0;--wp--preset--gradient--vivid-cyan-blue-to-vivid-purple:linear-gradient(135deg,#0693e3 0%,#9b51e0 100%);--wp--preset--gradient--light-green-cyan-to-vivid-green-cyan:linear-gradient(135deg,#7adcb4 0%,#00d082 100%);--wp--preset--gradient--luminous-vivid-amber-to-luminous-vivid-orange:linear-gradient(135deg,#fcb900 0%,#ff6900 100%);--wp--preset--gradient--luminous-vivid-orange-to-vivid-red:linear-gradient(135deg,#ff6900 0%,#cf2e2e 100%);--wp--preset--gradient--very-light-gray-to-cyan-bluish-gray:linear-gradient(135deg,#eee 0%,#a9b8c3 100%);--wp--preset--gradient--cool-to-warm-spectrum:linear-gradient(135deg,#4aeadc 0%,#9778d1 20%,#cf2aba 40%,#ee2c82 60%,#fb6962 80%,#fef84c 100%);--wp--preset--gradient--blush-light-purple:linear-gradient(135deg,#ffceec 0%,#9896f0 100%);--wp--preset--gradient--blush-bordeaux:linear-gradient(135deg,#fecda5 0%,#fe2d2d 50%,#6b003e 100%);--wp--preset--gradient--luminous-dusk:linear-gradient(135deg,#ffcb70 0%,#c751c0 50%,#4158d0 100%);--wp--preset--gradient--pale-ocean:linear-gradient(135deg,#fff5cb 0%,#b6e3d4 50%,#33a7b5 100%);--wp--preset--gradient--electric-grass:linear-gradient(135deg,#caf880 0%,#71ce7e 100%);--wp--preset--gradient--midnight:linear-gradient(135deg,#020381 0%,#2874fc 100%);--wp--preset--font-size--small:13px;--wp--preset--font-size--medium:20px;--wp--preset--font-size--large:36px;--wp--preset--font-size--x-large:42px;--wp--preset--spacing--20:.44rem;--wp--preset--spacing--30:.67rem;--wp--preset--spacing--40:1rem;--wp--preset--spacing--50:1.5rem;--wp--preset--spacing--60:2.25rem;--wp--preset--spacing--70:3.38rem;--wp--preset--spacing--80:5.06rem;--wp--preset--shadow--natural:6px 6px 9px rgba(0,0,0,.2);--wp--preset--shadow--deep:12px 12px 50px rgba(0,0,0,.4);--wp--preset--shadow--sharp:6px 6px 0px rgba(0,0,0,.2);--wp--preset--shadow--outlined:6px 6px 0px -3px #fff,6px 6px #000;--wp--preset--shadow--crisp:6px 6px 0px #000}:where(body){margin:0}:where(.is-layout-flex){gap:.5em}:where(.is-layout-grid){gap:.5em}body .is-layout-flex{display:flex}.is-layout-flex{flex-wrap:wrap;align-items:center}.is-layout-flex>:is(*, div){margin:0}body .is-layout-grid{display:grid}.is-layout-grid>:is(*, div){margin:0}body{padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px}:root :where(.wp-element-button, .wp-block-button__link){background-color:#32373c;border-width:0;color:#fff;font-family:inherit;font-size:inherit;font-style:inherit;font-weight:inherit;letter-spacing:inherit;line-height:inherit;padding-top:calc(.667em + 2px);padding-right:calc(1.333em + 2px);padding-bottom:calc(.667em + 2px);padding-left:calc(1.333em + 2px);text-decoration:none;text-transform:inherit}.has-black-color{color:var(--wp--preset--color--black) !important}.has-cyan-bluish-gray-color{color:var(--wp--preset--color--cyan-bluish-gray) !important}.has-white-color{color:var(--wp--preset--color--white) !important}.has-pale-pink-color{color:var(--wp--preset--color--pale-pink) !important}.has-vivid-red-color{color:var(--wp--preset--color--vivid-red) !important}.has-luminous-vivid-orange-color{color:var(--wp--preset--color--luminous-vivid-orange) !important}.has-luminous-vivid-amber-color{color:var(--wp--preset--color--luminous-vivid-amber) !important}.has-light-green-cyan-color{color:var(--wp--preset--color--light-green-cyan) !important}.has-vivid-green-cyan-color{color:var(--wp--preset--color--vivid-green-cyan) !important}.has-pale-cyan-blue-color{color:var(--wp--preset--color--pale-cyan-blue) !important}.has-vivid-cyan-blue-color{color:var(--wp--preset--color--vivid-cyan-blue) !important}.has-vivid-purple-color{color:var(--wp--preset--color--vivid-purple) !important}.has-black-background-color{background-color:var(--wp--preset--color--black) !important}.has-cyan-bluish-gray-background-color{background-color:var(--wp--preset--color--cyan-bluish-gray) !important}.has-white-background-color{background-color:var(--wp--preset--color--white) !important}.has-pale-pink-background-color{background-color:var(--wp--preset--color--pale-pink) !important}.has-vivid-red-background-color{background-color:var(--wp--preset--color--vivid-red) !important}.has-luminous-vivid-orange-background-color{background-color:var(--wp--preset--color--luminous-vivid-orange) !important}.has-luminous-vivid-amber-background-color{background-color:var(--wp--preset--color--luminous-vivid-amber) !important}.has-light-green-cyan-background-color{background-color:var(--wp--preset--color--light-green-cyan) !important}.has-vivid-green-cyan-background-color{background-color:var(--wp--preset--color--vivid-green-cyan) !important}.has-pale-cyan-blue-background-color{background-color:var(--wp--preset--color--pale-cyan-blue) !important}.has-vivid-cyan-blue-background-color{background-color:var(--wp--preset--color--vivid-cyan-blue) !important}.has-vivid-purple-background-color{background-color:var(--wp--preset--color--vivid-purple) !important}.has-black-border-color{border-color:var(--wp--preset--color--black) !important}.has-cyan-bluish-gray-border-color{border-color:var(--wp--preset--color--cyan-bluish-gray) !important}.has-white-border-color{border-color:var(--wp--preset--color--white) !important}.has-pale-pink-border-color{border-color:var(--wp--preset--color--pale-pink) !important}.has-vivid-red-border-color{border-color:var(--wp--preset--color--vivid-red) !important}.has-luminous-vivid-orange-border-color{border-color:var(--wp--preset--color--luminous-vivid-orange) !important}.has-luminous-vivid-amber-border-color{border-color:var(--wp--preset--color--luminous-vivid-amber) !important}.has-light-green-cyan-border-color{border-color:var(--wp--preset--color--light-green-cyan) !important}.has-vivid-green-cyan-border-color{border-color:var(--wp--preset--color--vivid-green-cyan) !important}.has-pale-cyan-blue-border-color{border-color:var(--wp--preset--color--pale-cyan-blue) !important}.has-vivid-cyan-blue-border-color{border-color:var(--wp--preset--color--vivid-cyan-blue) !important}.has-vivid-purple-border-color{border-color:var(--wp--preset--color--vivid-purple) !important}.has-vivid-cyan-blue-to-vivid-purple-gradient-background{background:var(--wp--preset--gradient--vivid-cyan-blue-to-vivid-purple) !important}.has-light-green-cyan-to-vivid-green-cyan-gradient-background{background:var(--wp--preset--gradient--light-green-cyan-to-vivid-green-cyan) !important}.has-luminous-vivid-amber-to-luminous-vivid-orange-gradient-background{background:var(--wp--preset--gradient--luminous-vivid-amber-to-luminous-vivid-orange) !important}.has-luminous-vivid-orange-to-vivid-red-gradient-background{background:var(--wp--preset--gradient--luminous-vivid-orange-to-vivid-red) !important}.has-very-light-gray-to-cyan-bluish-gray-gradient-background{background:var(--wp--preset--gradient--very-light-gray-to-cyan-bluish-gray) !important}.has-cool-to-warm-spectrum-gradient-background{background:var(--wp--preset--gradient--cool-to-warm-spectrum) !important}.has-blush-light-purple-gradient-background{background:var(--wp--preset--gradient--blush-light-purple) !important}.has-blush-bordeaux-gradient-background{background:var(--wp--preset--gradient--blush-bordeaux) !important}.has-luminous-dusk-gradient-background{background:var(--wp--preset--gradient--luminous-dusk) !important}.has-pale-ocean-gradient-background{background:var(--wp--preset--gradient--pale-ocean) !important}.has-electric-grass-gradient-background{background:var(--wp--preset--gradient--electric-grass) !important}.has-midnight-gradient-background{background:var(--wp--preset--gradient--midnight) !important}.has-small-font-size{font-size:var(--wp--preset--font-size--small) !important}.has-medium-font-size{font-size:var(--wp--preset--font-size--medium) !important}.has-large-font-size{font-size:var(--wp--preset--font-size--large) !important}.has-x-large-font-size{font-size:var(--wp--preset--font-size--x-large) !important}.woocommerce form .form-row .required{visibility:visible}.mc4wp-checkbox-wp-comment-form{clear:both;width:auto;display:block;position:static}.mc4wp-checkbox-wp-comment-form input{float:none;vertical-align:middle;-webkit-appearance:checkbox;width:auto;max-width:21px;margin:0 6px 0 0;padding:0;position:static;display:inline-block !important}.mc4wp-checkbox-wp-comment-form label{float:none;cursor:pointer;width:auto;margin:0 0 16px;display:block;position:static}.e-con.e-parent:nth-of-type(n+4):not(.e-lazyloaded):not(.e-no-lazyload),.e-con.e-parent:nth-of-type(n+4):not(.e-lazyloaded):not(.e-no-lazyload) *{background-image:none !important}@media screen and (max-height: 1024px){.e-con.e-parent:nth-of-type(n+3):not(.e-lazyloaded):not(.e-no-lazyload),.e-con.e-parent:nth-of-type(n+3):not(.e-lazyloaded):not(.e-no-lazyload) *{background-image:none !important}.e-con.e-parent:nth-of-type(n+3):not(.e-lazyloaded):not(.e-no-lazyload).nitro-lazy,.e-con.e-parent:nth-of-type(n+3):not(.e-lazyloaded):not(.e-no-lazyload) *.nitro-lazy{background-image:none !important}}@media screen and (max-height: 640px){.e-con.e-parent:nth-of-type(n+2):not(.e-lazyloaded):not(.e-no-lazyload),.e-con.e-parent:nth-of-type(n+2):not(.e-lazyloaded):not(.e-no-lazyload) *{background-image:none !important}.e-con.e-parent:nth-of-type(n+2):not(.e-lazyloaded):not(.e-no-lazyload).nitro-lazy,.e-con.e-parent:nth-of-type(n+2):not(.e-lazyloaded):not(.e-no-lazyload) *.nitro-lazy{background-image:none !important}}.e-con.e-parent:nth-of-type(n+4):not(.e-lazyloaded):not(.e-no-lazyload).nitro-lazy,.e-con.e-parent:nth-of-type(n+4):not(.e-lazyloaded):not(.e-no-lazyload) *.nitro-lazy{background-image:none !important}body{--j-body-color:#5a5a5a;--j-accent-color:#009ca6;--j-alt-color:#003a96;--j-heading-color:#121212}body,.jeg_newsfeed_list .tns-outer .tns-controls button,.jeg_filter_button,.owl-carousel .owl-nav div,.jeg_readmore,.jeg_hero_style_7 .jeg_post_meta a,.widget_calendar thead th,.widget_calendar tfoot a,.jeg_socialcounter a,.entry-header .jeg_meta_like a,.entry-header .jeg_meta_comment a,.entry-header .jeg_meta_donation a,.entry-header .jeg_meta_bookmark a,.entry-content tbody tr:hover,.entry-content th,.jeg_splitpost_nav li:hover a,#breadcrumbs a,.jeg_author_socials a:hover,.jeg_footer_content a,.jeg_footer_bottom a,.jeg_cartcontent,.woocommerce .woocommerce-breadcrumb a{color:#5a5a5a}a,.jeg_menu_style_5>li>a:hover,.jeg_menu_style_5>li.sfHover>a,.jeg_menu_style_5>li.current-menu-item>a,.jeg_menu_style_5>li.current-menu-ancestor>a,.jeg_navbar .jeg_menu:not(.jeg_main_menu)>li>a:hover,.jeg_midbar .jeg_menu:not(.jeg_main_menu)>li>a:hover,.jeg_side_tabs li.active,.jeg_block_heading_5 strong,.jeg_block_heading_6 strong,.jeg_block_heading_7 strong,.jeg_block_heading_8 strong,.jeg_subcat_list li a:hover,.jeg_subcat_list li button:hover,.jeg_pl_lg_7 .jeg_thumb .jeg_post_category a,.jeg_pl_xs_2:before,.jeg_pl_xs_4 .jeg_postblock_content:before,.jeg_postblock .jeg_post_title a:hover,.jeg_hero_style_6 .jeg_post_title a:hover,.jeg_sidefeed .jeg_pl_xs_3 .jeg_post_title a:hover,.widget_jnews_popular .jeg_post_title a:hover,.jeg_meta_author a,.widget_archive li a:hover,.widget_pages li a:hover,.widget_meta li a:hover,.widget_recent_entries li a:hover,.widget_rss li a:hover,.widget_rss cite,.widget_categories li a:hover,.widget_categories li.current-cat>a,#breadcrumbs a:hover,.jeg_share_count .counts,.commentlist .bypostauthor>.comment-body>.comment-author>.fn,span.required,.jeg_review_title,.bestprice .price,.authorlink a:hover,.jeg_vertical_playlist .jeg_video_playlist_play_icon,.jeg_vertical_playlist .jeg_video_playlist_item.active .jeg_video_playlist_thumbnail:before,.jeg_horizontal_playlist .jeg_video_playlist_play,.woocommerce li.product .pricegroup .button,.widget_display_forums li a:hover,.widget_display_topics li:before,.widget_display_replies li:before,.widget_display_views li:before,.bbp-breadcrumb a:hover,.jeg_mobile_menu li.sfHover>a,.jeg_mobile_menu li a:hover,.split-template-6 .pagenum,.jeg_mobile_menu_style_5>li>a:hover,.jeg_mobile_menu_style_5>li.sfHover>a,.jeg_mobile_menu_style_5>li.current-menu-item>a,.jeg_mobile_menu_style_5>li.current-menu-ancestor>a,.jeg_mobile_menu.jeg_menu_dropdown li.open>div>a{color:#009ca6}.jeg_menu_style_1>li>a:before,.jeg_menu_style_2>li>a:before,.jeg_menu_style_3>li>a:before,.jeg_side_toggle,.jeg_slide_caption .jeg_post_category a,.jeg_slider_type_1_wrapper .tns-controls button.tns-next,.jeg_block_heading_1 .jeg_block_title span,.jeg_block_heading_2 .jeg_block_title span,.jeg_block_heading_3,.jeg_block_heading_4 .jeg_block_title span,.jeg_block_heading_6:after,.jeg_pl_lg_box .jeg_post_category a,.jeg_pl_md_box .jeg_post_category a,.jeg_readmore:hover,.jeg_thumb .jeg_post_category a,.jeg_block_loadmore a:hover,.jeg_postblock.alt .jeg_block_loadmore a:hover,.jeg_block_loadmore a.active,.jeg_postblock_carousel_2 .jeg_post_category a,.jeg_heroblock .jeg_post_category a,.jeg_pagenav_1 .page_number.active,.jeg_pagenav_1 .page_number.active:hover,input[type="submit"],.btn,.button,.widget_tag_cloud a:hover,.popularpost_item:hover .jeg_post_title a:before,.jeg_splitpost_4 .page_nav,.jeg_splitpost_5 .page_nav,.jeg_post_via a:hover,.jeg_post_source a:hover,.jeg_post_tags a:hover,.comment-reply-title small a:before,.comment-reply-title small a:after,.jeg_storelist .productlink,.authorlink li.active a:before,.jeg_footer.dark .socials_widget:not(.nobg) a:hover .fa,div.jeg_breakingnews_title,.jeg_overlay_slider_bottom_wrapper .tns-controls button,.jeg_overlay_slider_bottom_wrapper .tns-controls button:hover,.jeg_vertical_playlist .jeg_video_playlist_current,.woocommerce span.onsale,.woocommerce #respond input#submit:hover,.woocommerce a.button:hover,.woocommerce button.button:hover,.woocommerce input.button:hover,.woocommerce #respond input#submit.alt,.woocommerce a.button.alt,.woocommerce button.button.alt,.woocommerce input.button.alt,.jeg_popup_post .caption,.jeg_footer.dark input[type="submit"],.jeg_footer.dark .btn,.jeg_footer.dark .button,.footer_widget.widget_tag_cloud a:hover,.jeg_inner_content .content-inner .jeg_post_category a:hover,#buddypress .standard-form button,#buddypress a.button,#buddypress input[type="submit"],#buddypress input[type="button"],#buddypress input[type="reset"],#buddypress ul.button-nav li a,#buddypress .generic-button a,#buddypress .generic-button button,#buddypress .comment-reply-link,#buddypress a.bp-title-button,#buddypress.buddypress-wrap .members-list li .user-update .activity-read-more a,div#buddypress .standard-form button:hover,div#buddypress a.button:hover,div#buddypress input[type="submit"]:hover,div#buddypress input[type="button"]:hover,div#buddypress input[type="reset"]:hover,div#buddypress ul.button-nav li a:hover,div#buddypress .generic-button a:hover,div#buddypress .generic-button button:hover,div#buddypress .comment-reply-link:hover,div#buddypress a.bp-title-button:hover,div#buddypress.buddypress-wrap .members-list li .user-update .activity-read-more a:hover,#buddypress #item-nav .item-list-tabs ul li a:before,.jeg_inner_content .jeg_meta_container .follow-wrapper a{background-color:#009ca6}.jeg_block_heading_7 .jeg_block_title span,.jeg_readmore:hover,.jeg_block_loadmore a:hover,.jeg_block_loadmore a.active,.jeg_pagenav_1 .page_number.active,.jeg_pagenav_1 .page_number.active:hover,.jeg_pagenav_3 .page_number:hover,.jeg_prevnext_post a:hover h3,.jeg_overlay_slider .jeg_post_category,.jeg_sidefeed .jeg_post.active,.jeg_vertical_playlist.jeg_vertical_playlist .jeg_video_playlist_item.active .jeg_video_playlist_thumbnail img,.jeg_horizontal_playlist .jeg_video_playlist_item.active{border-color:#009ca6}.jeg_tabpost_nav li.active,.woocommerce div.product .woocommerce-tabs ul.tabs li.active,.jeg_mobile_menu_style_1>li.current-menu-item a,.jeg_mobile_menu_style_1>li.current-menu-ancestor a,.jeg_mobile_menu_style_2>li.current-menu-item::after,.jeg_mobile_menu_style_2>li.current-menu-ancestor::after,.jeg_mobile_menu_style_3>li.current-menu-item::before,.jeg_mobile_menu_style_3>li.current-menu-ancestor::before{border-bottom-color:#009ca6}.jeg_post_share .jeg-icon svg{fill:#009ca6}.jeg_post_meta .fa,.jeg_post_meta .jpwt-icon,.entry-header .jeg_post_meta .fa,.jeg_review_stars,.jeg_price_review_list{color:#003a96}.jeg_share_button.share-float.share-monocrhome a{background-color:#003a96}h1,h2,h3,h4,h5,h6,.jeg_post_title a,.entry-header .jeg_post_title,.jeg_hero_style_7 .jeg_post_title a,.jeg_block_title,.jeg_splitpost_bar .current_title,.jeg_video_playlist_title,.gallery-caption,.jeg_push_notification_button>a.button{color:#121212}.split-template-9 .pagenum,.split-template-10 .pagenum,.split-template-11 .pagenum,.split-template-12 .pagenum,.split-template-13 .pagenum,.split-template-15 .pagenum,.split-template-18 .pagenum,.split-template-20 .pagenum,.split-template-19 .current_title span,.split-template-20 .current_title span{background-color:#121212}.jeg_midbar{height:60px}.jeg_midbar,.jeg_midbar.dark{background-color:#f7f7f7}.jeg_header .jeg_bottombar.jeg_navbar,.jeg_bottombar .jeg_nav_icon{height:60px}.jeg_header .jeg_bottombar.jeg_navbar,.jeg_header .jeg_bottombar .jeg_main_menu:not(.jeg_menu_style_1)>li>a,.jeg_header .jeg_bottombar .jeg_menu_style_1>li,.jeg_header .jeg_bottombar .jeg_menu:not(.jeg_main_menu)>li>a{line-height:60px}.jeg_header .jeg_bottombar,.jeg_header .jeg_bottombar.jeg_navbar_dark,.jeg_bottombar.jeg_navbar_boxed .jeg_nav_row,.jeg_bottombar.jeg_navbar_dark.jeg_navbar_boxed .jeg_nav_row{border-bottom-width:0px}.jeg_header .socials_widget>a>i.fa:before{color:#5a5a5a}.jeg_header .socials_widget.nobg>a>i>span.jeg-icon svg{fill:#5a5a5a}.jeg_header .socials_widget.nobg>a>span.jeg-icon svg{fill:#5a5a5a}.jeg_header .socials_widget>a>span.jeg-icon svg{fill:#5a5a5a}.jeg_header .socials_widget>a>i>span.jeg-icon svg{fill:#5a5a5a}.jeg_button_mobile .btn{background:#d33;color:#fff}.jeg_cart_icon.woocommerce .jeg_carticon{color:#000}.jeg_nav_search{width:50%}.jeg_footer .jeg_footer_heading h3,.jeg_footer.dark .jeg_footer_heading h3,.jeg_footer .widget h2,.jeg_footer .footer_dark .widget h2{color:#121212}.jeg_read_progress_wrapper .jeg_progress_container .progress-bar{background-color:#003ca9}body,input,textarea,select,.chosen-container-single .chosen-single,.btn,.button{font-family:"Helvetica Neue",Helvetica,Roboto,Arial,sans-serif}.jeg_header,.jeg_mobile_wrapper{font-family:"Helvetica Neue",Helvetica,Roboto,Arial,sans-serif}.jeg_main_menu>li>a{font-family:"Helvetica Neue",Helvetica,Roboto,Arial,sans-serif;font-size:12px;line-height:1px}.jeg_post_title,.entry-header .jeg_post_title,.jeg_single_tpl_2 .entry-header .jeg_post_title,.jeg_single_tpl_3 .entry-header .jeg_post_title,.jeg_single_tpl_6 .entry-header .jeg_post_title,.jeg_content .jeg_custom_title_wrapper .jeg_post_title{font-family:Montserrat,Helvetica,Arial,sans-serif}.jeg_post_excerpt p,.content-inner p{font-family:"Helvetica Neue",Helvetica,Roboto,Arial,sans-serif}.jeg_thumb .jeg_post_category a,.jeg_pl_lg_box .jeg_post_category a,.jeg_pl_md_box .jeg_post_category a,.jeg_postblock_carousel_2 .jeg_post_category a,.jeg_heroblock .jeg_post_category a,.jeg_slide_caption .jeg_post_category a{background-color:#3943b7}.jeg_overlay_slider .jeg_post_category,.jeg_thumb .jeg_post_category a,.jeg_pl_lg_box .jeg_post_category a,.jeg_pl_md_box .jeg_post_category a,.jeg_postblock_carousel_2 .jeg_post_category a,.jeg_heroblock .jeg_post_category a,.jeg_slide_caption .jeg_post_category a{border-color:#3943b7}.no_thumbnail .jeg_thumb,.thumbnail-container.no_thumbnail{display:none !important}.jeg_search_result .jeg_pl_xs_3.no_thumbnail .jeg_postblock_content,.jeg_sidefeed .jeg_pl_xs_3.no_thumbnail .jeg_postblock_content,.jeg_pl_sm.no_thumbnail .jeg_postblock_content{margin-left:0}.jeg_postblock_11 .no_thumbnail .jeg_postblock_content,.jeg_postblock_12 .no_thumbnail .jeg_postblock_content,.jeg_postblock_12.jeg_col_3o3 .no_thumbnail .jeg_postblock_content{margin-top:0}.jeg_postblock_15 .jeg_pl_md_box.no_thumbnail .jeg_postblock_content,.jeg_postblock_19 .jeg_pl_md_box.no_thumbnail .jeg_postblock_content,.jeg_postblock_24 .jeg_pl_md_box.no_thumbnail .jeg_postblock_content,.jeg_sidefeed .jeg_pl_md_box .jeg_postblock_content{position:relative}.jeg_postblock_carousel_2 .no_thumbnail .jeg_post_title a,.jeg_postblock_carousel_2 .no_thumbnail .jeg_post_title a:hover,.jeg_postblock_carousel_2 .no_thumbnail .jeg_post_meta .fa{color:#212121 !important}.jnews-dark-mode .jeg_postblock_carousel_2 .no_thumbnail .jeg_post_title a,.jnews-dark-mode .jeg_postblock_carousel_2 .no_thumbnail .jeg_post_title a:hover,.jnews-dark-mode .jeg_postblock_carousel_2 .no_thumbnail .jeg_post_meta .fa{color:#fff !important}.jeg_logo img{max-height:100% !important;height:70px !important;width:auto !important}.jeg_accountlink li .jeg_popuplink{-webkit-transform:translatex(0px) translatey(0px);-ms-transform:translatex(0px) translatey(0px);transform:translatex(0px) translatey(0px)}.jeg_midbar li:nth-child(2) .jeg_popuplink{display:none;visibility:hidden}.jeg_bottombar .container .jeg_nav_row .jeg_nav_left .item_wrap .jeg_nav_item .jeg_mainmenu_wrap .jeg_main_menu>.menu-item{-webkit-box-shadow:none;box-shadow:none}.jeg_bottombar .item_wrap .sub-menu{text-shadow:none}.popularpost_list .popularpost_item .jeg_socialshare{visibility:hidden}.jeg_singlepage .jeg_ad_article .ads-wrapper{-webkit-transform:translatex(0px) translatey(0px);-ms-transform:translatex(0px) translatey(0px);transform:translatex(0px) translatey(0px);background-color:#fff}.jeg_midbar li:nth-child(1) .jeg_popuplink{padding-left:10px}@media (max-width:700px){.jeg_viewport .jeg_nav_center img{padding-left:85px}.jeg_navbar_mobile .item_wrap .btn{color:#fff}}.single .single .content-inner{display:none}