Spironolactone ineffective for patients with preserved ejection fraction after myocardial infarction
1. In this randomized controlled trial, spironolactone did not significantly reduce death from cardiovascular causes or new or worsening heart ...
Tag: spironolactone
Mineralocorticoid receptor antagonists reduce hospitalizations in patients with heart failure with preserved or mildly reduced ejection fraction
1. Cardiovascular death and first heart failure hospitalization was reduced among HFrEF patients compared to HFmrEF and HFpEF patients. 2. ...
Spironolactone may be effective in the treatment of acne vulgaris
1. Spironolactone showed more effective improvement in acne at 12 and 24 weeks after treatment initiation as compared with the ...
Quick Take: Patiromer versus placebo to enable spironolactone use in patients with resistant hypertension and chronic kidney disease (AMBER)
1. Potassium binder therapy with patiromer can promote longer duration of spironolactone use for resistant hypertension in the setting of ...
2 Minute Medicine Rewind September 23, 2019
The clinical effectiveness of sertraline in primary care and the role of depression severity and duration (PANDA): a pragmatic, double-blind, ...
Renin-angiotensin system inhibition following transcatheter aortic valve replacement linked with lower cardiac mortality
1. Use of medications to inhibit the renin-angiotensin system (RAS) following transcatheter aortic valve replacement (TAVR) for severe aortic stenosis ...
Aldosterone antagonist therapy linked to reduced mortality following STEMI without heart failure
1. In this meta-analysis of available randomized clinical trials, use of aldosterone antagonist therapy in patients with preserved ejection fraction ...
![Spironolactone not beneficial in heart failure with preserved ejection fraction [TOPCAT trial]](https://www.2minutemedicine.com/wp-content/uploads/2014/04/Pulmonaryedema09-350x250.jpg)
Spironolactone not beneficial in heart failure with preserved ejection fraction [TOPCAT trial]
Image: CC/Wiki 1. There was no significant difference in the primary composite outcome (death from cardiovascular causes, aborted cardiac arrest, ...
The RALES trial: Spironolactone decreases all-cause mortality in heart failure patients [Classics Series]
Image: PD 1. Adding 25 mg of spironolactone to standard therapy reduces all-cause mortality in heart failure patients with an ...