Tag: treatment

Image: PD   1. Delaying the first round of triple intrathecal therapy (TIT) until peripheral blasts were cleared improved CNS control in children with newly diagnosed acute lymphoblastic leukemia (ALL) and made cranial radiotherapy unnecessary. Evidence rating level: 2 (Good) Study Rundown: As the CNS provides a refuge for recurrent acute lymphoblastic leukemia...
Image: PD 1. Both ß-blockers (-0.92 mmHg, p<0.001) and nitrates (-0.63 mmHg, p=0.011) were associated with a significantly lower intraocular pressure. 2. Statins and aspirin were initially associated with lower intraocular pressure, but were found to be due to concurrent use of ß-blockers. Evidence Rating Level: 2 (Good) Study Rundown: In this study,...
Image: PD 1. Over a 20-year period, China reduced prevalence of smear-positive tuberculosis by more than half by shifting tuberculosis treatment from hospitals to public health centers that implemented the directly observed treatment, short-course (DOTS) strategy. 2. The directly observed treatment, short-course (DOTS) regimen was particularly effective at reducing prevalence of...
Image: PD 1: Escalated-dose conformal radiotherapy with neoadjuvant androgen deprivation did not increase long-term, overall survival for patients with prostate cancer. 2: The escalated-dose regimen did result in prolonged biochemical progression-free survival, although with increased toxicity.  Evidence Rating: 1 (Excellent) Study Rundown: This study randomized men with T1b-T3a,N0,M0 prostate cancer with PSA levels...
Image: PD 1. Rates of diuretic use, intubation, and hospital admission do not differ between hypertensive, normotensive, and hypotensive patients with acutely decompensated heart failure. 2. Of hypertensive acute decompensated heart failure (ADHF) patients in the emergency department (ED), less than half receive vasodilators, and approximately one third do not receive...
Image: PD  1. Study found no significant differences in treatment outcomes between ibuprofen, paracetamol, combinations of the therapies, and steam inhalation in treating symptoms associated with respiratory tract infections. 2. Data from this study contradicts an earlier Cochrane review study which showed steam inhalation to provide a marginal benefit to patients...
Image: PD 1. Parents’ baseline preferences for ADHD medication and behavioral therapy (BT) are associated with subsequent initiation of each treatment.  2. The goal of improved academic achievement was associated with medication initiation, whereas the goals of improved behavioral compliance and interpersonal relationships were associated with BT initiation.  Evidence Rating Level: 2...
Image: PD AML 1. Rituximab use is linked with a reduction in chronic graft-vs-host disease following peripheral blood stem cell transplantation. 2. Rituximab is also linked with improved survival following transplantation compared to controls. Evidence Rating Level: 2 (Good) Study rundown: Following peripheral blood stem cell transplantation, chronic GVHD (graft-vs-host disease) is a...
Image: PD 1. Home-based therapy intervention that provides a support structure via a group program increases the distance and speed at which patients with PAD can ambulate. 2. There are very limited medical treatments for peripheral artery disease.  Evidence Rating Level: 1 (Excellent) Study Rundown: This study sought to provide evidence for the...