• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • 2MM Podcast
  • Write for us
  • Contact Us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Dermatology

Nivolumab plus ipilimumab improved long-term survival in patients with advanced melanoma  

byJamie ParkandSze Wah Samuel Chan
December 13, 2021
in Dermatology, Oncology
Reading Time: 2 mins read
0
Share on FacebookShare on Twitter

1. The 6.5-year progression-free survival for the nivolumab combination group, nivolumab group and in the ipilimumab group were 34%, 29% and 7%, respectively.

2. There were no new safety signals that were identified since the 5-year analysis.

Evidence Rating Level: 1 (Excellent)

Study Rundown: Patients with advanced melanoma have improved survival outcomes from  immune checkpoint inhibitors and BRAF- and MEK-targeted therapies. Previous phase II CheckMate 069 and phase III CheckMate 067 trials established nivolumab and ipilimumab as a standard care option for patients with metastatic melanoma. The 5-year follow-up overall survival (OS) rate from the phase III CheckMate 067 study was 52% for the nivolumab plus ipilimumab group, 44% for nivolumab and 26% for those receiving ipilimumab. To explore long-term outcomes beyond the 5 years follow-up period, this study aimed to evaluate the 6.5-year efficacy and safety outcomes from the CheckMate 067 study. Both efficacy primary end points (progression-free survival (PFS) and overall survival (OS)) were longer in the nivolumab combination compared to the monotherapy group at the 77 months minimum follow-up. The 6.5-year PFS rates for the nivolumab combination group, nivolumab monotherapy group and in the ipilimumab group were 34%, 29% and 7%, respectively. The median OS for the nivolumab combination group, nivolumab monotherapy group and in the ipilimumab group were 72.1 months, 36.9 months and 19.9 months respectively. There were no new safety signals reported since the last safety analysis cutoff. Overall, this study demonstrated that nivolumab plus ipilimumab or nivolumab alone shows promise in its long-term efficacy and safety profile to treat patients with advanced melanoma.

Click to read the study in The Journal of Clinical Oncology

Relevant Reading: Five-year survival with combined nivolumab and ipilimumab in advanced melanoma

RELATED REPORTS

2 Minute Medicine: Pharma Roundup – Gastric Immunotherapy Gains, Prostate Pill Expansion, Five-Minute Myeloma Dosing, and Streamlined CAR-T Access [July 8th 2025]

Nivolumab plus ipilimumab improves survival over lenvatinib or sorafenib in liver cancer

2 Minute Medicine: Pharma Roundup – Perioperative Immunotherapy Efficacy, Expanded Prostate Cancer Indication, Rapid Subcutaneous Myeloma Administration, and Regulatory Compliance Findings [June 4 2025]

In-Depth [randomized controlled trial]: Patients were eligible if they had previously untreated, unresectable or metastatic stage III or IV melanoma with known BRAF V600 mutation status. The primary endpoints were progression-free survival (PFS) and overall survival (OS) in the combination or the nivolumab group versus the ipilimumab group. In total, 1296 patients were enrolled in the study between July 2013 to March 2014 and 945 were randomly, equally assigned to each treatment group (314 to combination therapy, 316 to nivolumab, 315 to ipilimumab). The minimum follow-up period for the study was 77 months at the October 2020 data cutoff. The median follow-up for each group were the following: combination (57.5 months), nivolumab (36.0 months) and ipilimumab (18.6 months). The median investigator assessed PFS in the combination group was 11.5 months (95% confidence interval [CI]: 8.7-19.3), 6.9 months (95% CI: 5.1-10.2) in the nivolumab group and 2.9 months (95% CI: 2.8-3.2) in the ipilimumab group. The median OS for the combination group, nivolumab group and in the ipilimumab group were 72.1 months (95% CI: 38.2 to not reached), 36.9 months (95% CI: 28.2-58.7) and 19.9 months (95% CI: 16.8-24.6) respectively. 11 patients (3 in combination, 3 in nivolumab, 2 in ipilimumab therapy) died between the previous 5-year analysis and the current analysis and are considered to be unrelated to the treatment.

Image: PD

©2021 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

Tags: advanced melanomaanti-PD-L1 resistant melanomaimmunotherapy
Previous Post

Poziotinib reduces tumour size in patients with previously treated HER2 mutation positive non-small-cell lung cancer

Next Post

Suicide prevention videos may help improve suicidal ideation and help seeking in adolescents

RelatedReports

2 Minute Medicine: Pharma Roundup: Price Hikes, Breakthrough Approvals, Legal Showdowns, Biotech Expansion, and Europe’s Pricing Debate [May 12nd, 2025]
Pharma

2 Minute Medicine: Pharma Roundup – Gastric Immunotherapy Gains, Prostate Pill Expansion, Five-Minute Myeloma Dosing, and Streamlined CAR-T Access [July 8th 2025]

July 8, 2025
Prognostic indicators for transarterial chemoembolization in patients with hepatocellular carcinoma with extrahepatic spread identified
AI Roundup

Nivolumab plus ipilimumab improves survival over lenvatinib or sorafenib in liver cancer

June 12, 2025
2 Minute Medicine: Pharma Roundup: Price Hikes, Breakthrough Approvals, Legal Showdowns, Biotech Expansion, and Europe’s Pricing Debate [May 12nd, 2025]
Pharma

2 Minute Medicine: Pharma Roundup – Perioperative Immunotherapy Efficacy, Expanded Prostate Cancer Indication, Rapid Subcutaneous Myeloma Administration, and Regulatory Compliance Findings [June 4 2025]

June 4, 2025
Lessons from real-world implementation of lung cancer screening
Chronic Disease

Ivonescimab improves survival in advanced non-small cell lung cancer

April 30, 2025
Next Post
Parents often unaware of adolescents’ suicidal thoughts

Suicide prevention videos may help improve suicidal ideation and help seeking in adolescents

#VisualAbstract: Mohs micrographic surgery is more cost effective than wide local excision for T2a cutaneous squamous cell carcinomas

#VisualAbstract: Mohs micrographic surgery is more cost effective than wide local excision for T2a cutaneous squamous cell carcinomas

Resident involvement may not increase postoperative complications in neurosurgery

Pericardiotomy after cardiac surgery may reduce the incidence of postoperative atrial fibrillation

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • St. Louis hospital-based violence intervention program did not significantly affect reinjury outcomes
  • Glucagon-like peptide-1 receptor agonists may increase risk of reflux in patients with type 2 diabetes
  • Vaporized nicotine products may be effective for smoking cessation among people with social disadvantage
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
No Result
View All Result

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.