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Olanzapine discontinuation leads to higher relapse in depression with psychosis
1. In this randomized controlled trial, patients with Major depressive disorder with psychotic features who were stable on olanzapine and...
Poor blood pressure control from mid- through late-life increases dementia risk
1. In this prospective cohort study, patients with midlife hypertension and either late-life hypertension or hypotension had higher risks of...
Polygenic risk and lifestyle factors independently influence dementia risk
1. In this retrospective cohort study, patients with high polygenic risk scores and unhealthy lifestyle factors were more likely to...
Alzheimer’s Disease imaging biomarkers slightly improve prediction of memory decline
1. In this prospective cohort, Alzheimer’s Disease biomarkers derived from imaging, namely amyloid, tau, and cortical thickness estimates, had a...
Amyloid-PET imaging leads to changes in management in patients with dementia
1. In this prospective cohort study, changes in clinical management occurred after amyloid-PET imaging for a majority of patients with...
Midlife diet unlikely to affect dementia risk
1. In this prospective cohort study, a healthier diet in midlife did not affect the risk of developing dementia compared...
The RAINBOW Trial: Integrated treatment for depression and obesity likely to have modest benefit
1. In this randomized controlled trial, integrated behavioral weight loss treatment, problem-solving therapy, and as needed antidepressant treatment led to...
Nurse-led psychological intervention does not reduce PTSD symptoms in ICU patients
1. In this randomized clinical trial, nurse-led psychological interventions did not reduce PTSD risk at 6 months compared to care...
USPSTF: Counseling interventions likely to prevent perinatal depression
1. In this systematic review and meta-analysis, counseling interventions were found to help prevent the development of perinatal depression, primarily...
EEG-guided anesthetic administration unlikely to reduce post-operative delirium
1. In this randomized controlled trial, EEG-guided anesthetic administration during surgical interventions did not reduce the incidence of delirium compared...
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