Prenatal administration of novel compound treats Down syndrome in mice [PreClinical]
1. A chemical library screen identified a compound (termed altered generation of neurons, or ALGERNON) that promoted the proliferation of...
Targeting senescent cells prevents age-related bone loss in mice [PreClinical]
1. When three therapies that eliminate senescent cells were separately tested on aged mice, the animals demonstrated improved bone microarchitecture...
![Tumor-specific mutant antigens are potential targets for cancer therapy [PreClinical]](https://www.2minutemedicine.com/wp-content/uploads/2014/12/mouse-e1417555547919-350x250.jpg)
Adiponectin treats some symptoms of polycystic ovarian syndrome in mice [PreClinical]
1. In mouse models of polycystic ovarian syndrome (PCOS), elevated adiponectin levels ameliorated metabolic dysfunction. 2. However, adiponectin was unable...
CRISPR-Cas9 corrects hypertrophic cardiomyopathy gene mutation in human preimplantation embryos [PreClinical]
1. The gene editing tool CRISPR-Cas9 was used to correct a mutant paternal MYBPC3 allele in human preimplantation embryos. 2....
Small-molecule inhibitor may reduce chemotherapy-associated metastases [PreClinical]
1. In a mouse model of breast cancer, treatment with the chemotherapy paclitaxel (Ptx) enhanced tumor cell dissemination and the...
![Metformin treats Fragile X syndrome symptoms in mice [PreClinical]](https://www.2minutemedicine.com/wp-content/uploads/2017/07/Metformin_500mg_Tablets-350x250.jpg)
Metformin treats Fragile X syndrome symptoms in mice [PreClinical]
1. Following treatment with metformin, mouse models of Fragile X syndrome (FXS) demonstrated restored neurological signaling activity and synaptic function....
Combination treatment with calcineurin inhibitors and IL-2 enhances transplant survival [PreClinical]
1. Blood from liver transplant patients treated with a calcineurin inhibitor (CNI) showed increased levels of apoptotic regulatory T cells...
Drug improves cystic fibrosis pulmonary inflammation and protein function [PreClinical]
1. Thymosin α1 (Tα1), an immunomodulatory drug currently in use, decreased lung inflammation in a mouse model of cystic fibrosis...
Low-cost biochip isolates cells for clinical diagnosis [PreClinical]
1. Researchers manufactured a microfluidic biochip, using an inkjet printing system to apply conductive nanoparticles to a polymer substrate. 2....
Lipid nanoparticles deliver messenger RNA for hemophilia B protein replacement therapy [PreClinical]
1. A lipid nanoparticle (LNP) delivery system was developed to introduce factor IX (FIX) messenger RNA (mRNA) into a FIX...