Small-molecule inhibitor may reduce chemotherapy-associated metastases [PreClinical]
1. In a mouse model of breast cancer, treatment with the chemotherapy paclitaxel (Ptx) enhanced tumor cell dissemination and the...
Novel imaging agent could enable pulmonary fibrosis diagnosis and monitoring [PreClinical]
1. A gallium-labeled, collagen-binding peptide (68Ga-CBP8) specifically identified fibrotic tissue via positron emission tomography (PET) imaging in two mouse...
![pH-sensitive nanoparticles reduce cancer growth by deoxygenating tumor tissue [PreClinical]](https://www.2minutemedicine.com/wp-content/uploads/2017/01/Mesoporous_Silica_Nanoparticle-350x250.jpg)
pH-sensitive nanoparticles reduce cancer growth by deoxygenating tumor tissue [PreClinical]
1. Under mildly acidic in vitro conditions, silicon-based nanoparticles (NPs) effectively scavenged dissolved and hemoglobin-bound oxygen (O2) and reduced breast...
Antibody-based imaging can monitor prostate cancer progression [PreClinical]
1. In a mouse model of prostate cancer (PCa), a radiolabeled antibody (89Zr-11B6) targeting the androgen receptor (AR) pathway noninvasively...
Protein therapy combined with stem cell transplantation repairs stroke-induced brain damage [PreClinical]
1. Neural stem cell (NSC) transplantation and subsequent treatment with a variant of activated protein C (3K3A-APC) improved engraftment...
Correcting NAD+ depletion may improve muscular degeneration in Duchenne muscular dystrophy [PreClinical]
1. Dietary supplementation with nicotinamide riboside (NR), a form of vitamin B3 that acts as a precursor to nicotinamide adenine...
Small molecule inhibitor may resolve parasitic infections of neglected tropical diseases [PreClinical]
1. In several mouse models, a novel small molecule inhibitor, GNF6702 (GNF), effectively cleared infections of parasites that cause leishmaniasis,...
Blocking fatty acid synthesis may curb lung cancer growth [PreClinical]
1. ND-646, a small molecule inhibitor of FASyn, an enzyme involved in fatty acid synthesis, caused reduced growth and viability of...
Targeted thyroid hormone delivery reduces off-target effects [PreClinical]
1. Delivery of a hybridized form of glucagon and the thyroid hormone T3 (G/T3) improved signs of metabolic syndromes including...
Improving heat-shock protein levels shows efficacy against lysosomal storage diseases [PreClinical]
1. Treatment with recombinant heat-shock protein 70 (rHSP70) reduced lysosomal enlargement in cells isolated from patients with various lysosomal storage...