• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • Write for us
  • Contact us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Chronic Disease

Targeting senescent cells prevents age-related bone loss in mice [PreClinical]

byCorinne FoleyandJessica Lau
September 25, 2017
in Chronic Disease, Preclinical
Reading Time: 3 mins read
0
Share on FacebookShare on Twitter

1. When three therapies that eliminate senescent cells were separately tested on aged mice, the animals demonstrated improved bone microarchitecture and increased bone strength.

2. Young mice were not affected by any of the therapies, suggesting that the therapeutic approach of targeting senescent cells affected bone loss associated with aging.

Evidence Rating Level: 1 (Excellent)

Study Rundown: With age, certain cells accumulate DNA damage and become non-proliferating senescent cells. Because these cells express biomarkers such as p16Ink4a, they avoid apoptosis. Senescent cells have been identified in aged bones and are known to impair normal tissue functioning. The researchers in this study used three approaches to eliminate senescent cells and assessed their effects in preventing bone loss and restoring function.

In the first approach, researchers used transgenic mice containing a gene that eliminated senescent cells upon drug administration. After drug administration, these mice had improved spinal and femoral bone architecture, as well as increased bone strength. In the second, more clinically relevant approach for targeting senescent cells, mice were administered a combination of senolytic drugs that are currently clinically used for other indications, dasatinib and quercetin (D + Q). Treated mice had improved spinal bone microarchitecture and femoral bone strength. Finally, the efficacy of JAK inhibitors (JAKi) was assessed due to their known role in inhibiting the harmful functions of senescent cells. Results obtained in this model were similar to those from the other approaches.

Using three different approaches, the researchers in this study demonstrated the efficacy of targeting senescent cells to improve bone loss associated with aging. With the use of currently approved drugs, these data have increased clinical significance; however, the approach needs to be assessed in humans and compared to current drugs used for age-related bone loss.

Click here to read this study in Nature Medicine

RELATED REPORTS

#VisualAbstract: Bimekizumab shows a favourable 2-year safety profile in patients with moderate to severe plaque psoriasis

Medical cannabis provides little improvement to sleep in chronic pain patients

Alzheimer disease in individuals with Down syndrome has similar variability in age of onset and mortality rate as autosomal dominant forms

Relevant Reading: Bone cell senescence: Mechanisms and perspectives

In-Depth [animal study]: The first approach used 20-month-old female INK-ATTAC mice, which contained a transgene that eliminated p16Ink4a-positive cells following the administration of the drug AP20187. After four months of drug administration, dual-energy X-ray absorptiometry was performed to assess areal bone mineral density. The mice demonstrated improvements in the microarchitecture of the spine trabecular bone as well as increased cortical thickness of the femur (p < 0.05). Compression loading tests were performed with a servohydraulic test system to assess the bone strength of these mice, and the transgenic mice demonstrated a significant increase in bone strength (p < 0.05). In contrast, young (12-month-old) transgenic mice demonstrated no change in these parameters following drug administration.

In the second approach to target senescent cells, the researchers used senolytic drugs, D + Q, that are currently used clinically. When 20-month-old male C57BL/6 mice were treated with D + Q for four months, they showed decreased p16Ink4a mRNA expression (p < 0.01). The mice showed improved cortical microarchitecture of the spine, along with significantly increased cortical thickness and bone strength of the femur (p < 0.05).

Finally, the JAKi ruxolitinib was used to indirectly target senescent cells in 22-month-old male C57BL/6 mice. Results were similar to those from the previous two approaches; treated mice demonstrated improved trabecular bone microarchitecture of the spine and femoral bone strength (p < 0.05). Young (7-month-old) mice did not show such changes in bone parameters. However, this treatment resulted in systemic effects, including altered cytokine levels.

Image: PD

©2017 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

Previous Post

Adiponectin treats some symptoms of polycystic ovarian syndrome in mice [PreClinical]

Next Post

Patient age may impact hospital rankings based on acute myocardial infarction mortality data

RelatedReports

#VisualAbstract: Bimekizumab shows a favourable 2-year safety profile in patients with moderate to severe plaque psoriasis
StudyGraphics

#VisualAbstract: Bimekizumab shows a favourable 2-year safety profile in patients with moderate to severe plaque psoriasis

May 27, 2022
Parental cannabis use increasing, cigarette use decreasing
Chronic Disease

Medical cannabis provides little improvement to sleep in chronic pain patients

May 27, 2022
Genetic risk assessment for Alzheimer’s disease does not increase anxiety, depression or stress
Chronic Disease

Alzheimer disease in individuals with Down syndrome has similar variability in age of onset and mortality rate as autosomal dominant forms

May 26, 2022
#VisualAbstract: Ruxolitinib shows long-term safety and efficacy in inadequately controlled polycythaemia vera without splenomegaly
StudyGraphics

#VisualAbstract: Ruxolitinib shows long-term safety and efficacy in inadequately controlled polycythaemia vera without splenomegaly

May 26, 2022
Next Post
Antiarrhythmic drugs have no survival benefit in shock-refractory out-of-hospital cardiac arrest

Patient age may impact hospital rankings based on acute myocardial infarction mortality data

Stochastic resonance stimulation may decrease apnea of prematurity

Chronic auditory toxicity linked to peak unbound bilirubin levels

Standardized central line care practices reduce bloodstream infections

Age, race associated with end-of-life interventions in children with cancer

License Our Award-Winning Physician-Written Medical News and Visual Abstracts

2 Minute Medicine is the leading authoritative medical news licensing service, and the only with reports written by practicing doctors.

LICENSE CONTENT

Get 2MM+ Premium Access

No ads & unlimited access to all current reports, over 9000 searchable archived reports, visual abstracts, Weekly Rewinds, and the online edition of The Classics Series™ textbook.

Subscription Options
2 Minute Medicine

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • #VisualAbstract: Bimekizumab shows a favourable 2-year safety profile in patients with moderate to severe plaque psoriasis
  • Medical cannabis provides little improvement to sleep in chronic pain patients
  • Alzheimer disease in individuals with Down syndrome has similar variability in age of onset and mortality rate as autosomal dominant forms
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.