Rare APOE missense variants V236E and R251G associated with substantial reduction in risk of Alzheimer disease
1. APOE ε3 (V236E) and APOE ε4 (R251G), 2 rare missense genetic variants, both had a substantial association with reducing...
Late and moderate preterm birth associated with increased cardiometabolic risk scores in young children
1. This retrospective cohort study using the TARGet Kids! Cohort demonstrated that late and moderate preterm birth was significantly associated...
Unmarried status associated with an increased risk of mortality in Asian populations
1. This cohort study found that among 623,140 individuals participating in the Asia Cohort Consortium, being unmarried demonstrated a higher...
Decline in gait speed paired with domain-specific cognition decline may be a useful screening assessment for dementia
1. A decline in gait speed paired with domain-specific cognitive decline proved to be strongly correlated with subsequent development of...
Alzheimer disease in individuals with Down syndrome has similar variability in age of onset and mortality rate as autosomal dominant forms
1. This systematic review and meta-analysis demonstrated that the onset of Alzheimer disease in people with Down syndrome is as...
Early onset Lewy Body Dementia is more clinically distinct from Alzheimer Dementia than late onset Lewy Body Dementia
1. Select features distinguish early-onset Lewy Body Dementia from early-onset Alzheimer dementia, including: hallucinations, slowness, apathy and motor deterioration. 2....
Operating the day after performing surgery the previous night not associated with adverse patient outcomes
1. This cross-sectional study demonstrated no significant increase in major surgical complications or mortality when attending physician surgeons operated the...
Oral methylprednisolone may reduce risk of progressive renal failure in patients with IgA nephropathy: TESTING Trial
1. This randomized controlled trial found that high dose methylprednisolone for 6-9 months reduced rates of significantly declining kidney function,...
Endovascular abdominal aortic aneurysm repair may be associated with higher overall mortality and complications compared to open repair
1. In this retrospective cohort study, endovascular aneurysm repair was associated with significantly higher rates of long-term rupture and reintervention...
Awake prone positioning does not seem to offer benefit in reducing endotracheal intubation for COVID-19-induced acute respiratory failure: COVI-PRONE trial
1. This randomized clinical trial demonstrated no difference in the risk of endotracheal intubation requirement at 30 days between awake...
