Early anticoagulation after stroke decreases recurrence without increasing bleeding in patients with atrial fibrillation
1. Recurrent ischemic stroke rates were significantly reduced in patients who started DOAC within 4 days of an acute ischemic...
Retifanlimab improves progression-free survival in advanced squamous cell anal carcinoma
1. Progression-free survival was significantly greater in retifanlimab compared to placebo. 2. Serious and grade 3 or more adverse events...
Relacorilant plus nab-paclitaxel improves survival in platinum-resistant ovarian cancer patients
1. Progression-free and overall survival were greater in relacorilant plus nab-paclitaxel compared to nab-paclitaxel alone. 2. The rate of adverse...
Novel inhibitory antibody, MAR001, lowers triglycerides and remnant cholesterol in humans
1. ANGPTL4 inhibition decreased triglyceride and remnant cholesterol levels by over 50%. 2. MAR001 was well-tolerated with no significant treatment-related...
Abbreviated MRI is superior to whole-breast ultrasound for detection of cancer in dense breasts
1. Abbreviated MRI detected three times as many invasive cancers compared with ABUS. 2. Contrast-enhanced mammography detected a greater number...
Nivolumab plus ipilimumab improves survival over lenvatinib or sorafenib in liver cancer
1. Median overall survival was 3.1 months greater in the nivolumab plus ipilimumab group. 2. Grade 3-4 treatment-related adverse events...
Early induction of labour reduces shoulder dystocia rates in large for gestational age fetuses
1. Shoulder dystocia was less common in the early induction group compared to standard care. 2. Serious adverse events were...
Obicetrapib and ezetimibe combination therapy lowers LDL cholesterol in high-risk patients
1. FDC obicetrapib plus ezetimibe significantly decreased LDL cholesterol levels by 48.6% compared to placebo. 2. Serious adverse events were...
Semaglutide improves walking ability in patients with peripheral artery disease and type 2 diabetes
1. Maximum walking distance at 52 weeks was significantly improved with semaglutide. 2. There were fewer treatment-related serious adverse events...
Oral gepotidacin is non-inferior to standard therapy for uncomplicated urogenital gonorrhea
1. Gepotidacin was non-inferior to ceftriaxone plus azithromycin for the primary outcome of microbiological success. 2. There were no serious...
