1. A G551D missense mutation in the cystic fibrosis transmembrane conductance receptor (CFTR) is a genetic cause of cystic fibrosis...

1. Haploinsufficiency of Sim1 or Mc4r in the hypothalamus result in an obesity phenotype in mice and humans. 2. In...

1. Truncating mutations in cardiac myosin-binding protein C (MYBPC3) are a common genetic cause of hypertrophic cardiomyopathy. 2. Haploinsufficiency of...

1. IL-2 is a central cytokine that enhances the immune response, with considerable potential for the treatment of cancer. 2....

1. The clinical manifestations of preeclampsia result largely from excess circulating soluble vascular endothelial growth factor receptor (sFLT1), produced by...

1. α-melanocyote stimulating hormone (α -MSH) and its analogs can bind tightly to the melanocortin-1 receptor (MC1R), a G protein-coupled...

1. Mutations in the gene encoding dystrophin, a large scaffolding protein that supports muscle cell structure, result in Duchenne muscular...

1. Mu opioid peptide (MOP) receptor agonists provide effective pain relief, but are associated with severe side effects such as...

1. Post-translational detyrosination of microtubules results in resistance to cardiomyocyte sarcomere shortening and stretch. 2. Pharmacologic and genetic strategies to...

1. Comparative profiling of wounds induced in the oral mucosa versus skin revealed expression of genes that prime the oral...