Decrease in medication use among US children and adolescents
1. While overall prescribing of medications decreased compared to the early 2000s, the use of ADHD medication, asthma medicine, and...
Coaching to improve water intake does not improve kidney function in adults with chronic kidney disease
1. In this randomized controlled trial, coaching to improve daily fluid intake did not improve kidney function in patients with...
Glyburide is not non-inferior to insulin in reducing perinatal complications in gestational diabetes
1. In this randomized controlled trial, glyburide was not non-inferior in terms of the composite rate of macrosomia, neonatal hypoglycemia,...
SGLT-2 inhibitors and GLP-1 agonists associated with better mortality outcomes than DPP-4 inhibitors for type 2 diabetes
1. SGLT-2 or GLP-1 agonists were associated with lower mortality than DPP-4 inhibitors, placebo, or no treatment. 2. Use of...
No significant benefit of long-acting muscarinic antagonists over long-acting beta-agonists in reducing exacerbation risk in uncontrolled, persistent asthma
1. Adjunct long-acting muscarinic antagonist (LAMA) use with corticosteroids was associated with reduced exacerbation risk compared with placebo in patients...
Significant variation in mortality trends in substance use disorders among US counties
1. Mortality rates decreased for alcohol use disorders, self-harm, and interpersonal violence between 1980 and 2014. 2. Mortality rates for...
Meropenem-vaborbactam non-inferior to piperacillin-tazobactam for complicated urinary tract infections: The TANGO I trial
1. In this randomized controlled trial, meropenem-vaborbactam was found to be non-inferior to piperacillin-tazobactam for treating complicated urinary tract infections...
Effect of low-fat vs low-carbohydrate diet on weight loss in overweight adults
1. No significant difference in weight change between a healthy low-fat diet and a healthy low-carbohydrate diet. 2. Genotype pattern...
Affordable Care Act likely to lead to better prenatal care for women under 26
1. Ability to stay on parents’ insurance plan through the Affordable Care Act (ACA) was associated with a modest reduction...
High recurrence of gastroesophageal reflux disease in patients treated with laparoscopic antireflux surgery
1. Among patients receiving laparoscopic antireflux surgery, 17.7% experienced recurrent GERD requiring medication or secondary antireflux surgery 2. Factors associated...
