• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • Write for us
  • Contact us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Cardiology

Effect of low-fat vs low-carbohydrate diet on weight loss in overweight adults

byQasim HussainiandDaniel Fisher
February 27, 2018
in Cardiology, Chronic Disease, Endocrinology, Gastroenterology, Public Health
Reading Time: 2 mins read
0
Share on FacebookShare on Twitter

1. No significant difference in weight change between a healthy low-fat diet and a healthy low-carbohydrate diet.

2. Genotype pattern or insulin secretion was not associated with dietary effects on weight loss

Evidence Rating Level: 1 (Excellent)

Study Rundown: Though the balance of macronutrients, such as carbohydrates and fats, have been thought to influence the success of weight loss strategies, there is great variability between those on a particular diet. While some have posited that genetic predisposition and insulin secretion patterns may explain this variability, these hypotheses have yet to be rigorously tested. In this randomized controlled trial, it was tested whether a set of 3 SNPs or baseline insulin secretion played a role in the success of a healthy low-fat (HLF) versus a healthy low-carbohydrate (HLC) diet to influence weight loss. The study found no differences in weight loss between the two diets, though both did result in improvements in body weight. In addition, neither the SNPs nor baseline insulin secretion influenced the rate or weight loss.

Overall, the rigorous design and appropriate number of subjects largely supports the conclusions that neither type of macronutrient, 3 SNP genotype, nor baseline insulin secretion greatly influences the ability of individuals to lose weight. As there still remained wide variability of subjects to lose weight within each group, this further suggests that the variables tested here are unlikely to impact a clinically meaningful amount of weight loss. While there are some limitations to this study, including poor generalizability across race or ethnicity and unknown impact of other genetic factors, this study strongly supports the conclusions that macronutrient make up is minimally important for success of weight loss.

Click to read the study, published in JAMA

Relevant Reading: The Merits of Subtyping Obesity: One Size Does Not Fit All

RELATED REPORTS

Tirzepatide reduces body weight and improves cardiometabolic function in patients with obesity

#VisualAbstract: Tirzepatide Once Weekly for the Treatment of Obesity

Improved diet quality may be associated with increased longevity and better aging in Israeli adults

In-Depth [randomized controlled trial]: A total of 609 participants (mean age 40 years, 57% women, mean BMI 33, 79% completed study) were recruited from the Stanford and San Francisco Bay area and were randomized to HLC (30%), HLF (40%), or no intervention (30%). Some major criteria for exclusion included uncontrolled hypertension or metabolic disease, diabetes, cancer, heart, renal, or liver disease, or being pregnant or lactating. Intervention involved 22 instructional sessions over 12 months for both diet groups. Weight change at 12 months was -5.3 kg for HLF diet and -6.0 kg for HLC diet (difference 0.70, CI95 -0.21 to 1.60). No significant diet x genotype interaction (p = 0.20) or diet x insulin secretion interaction (p = 0.47) was found.

Image: PD

©2018 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

Tags: dietobesity
Previous Post

Talk therapy, modified for literacy level, helps ease chronic pain for disadvantaged populations

Next Post

2 Minute Medicine Rewind February 26, 2018

RelatedReports

Many new pediatric asthma cases attributable to obesity
Cardiology

Tirzepatide reduces body weight and improves cardiometabolic function in patients with obesity

July 22, 2022
#VisualAbstract: Tirzepatide Once Weekly for the Treatment of Obesity
StudyGraphics

#VisualAbstract: Tirzepatide Once Weekly for the Treatment of Obesity

July 7, 2022
Improved glycemic control in type 1 diabetics on very low-carbohydrate diets
Wellness

Improved diet quality may be associated with increased longevity and better aging in Israeli adults

June 28, 2022
Meeting families, demographic information affect child abuse work-up
Pediatrics

Subsidization of supermarkets may help reduce obesity risk in children

June 27, 2022
Next Post
Total knee replacement with post-surgical regimen yields greater relief vs nonsurgical treatment alone

2 Minute Medicine Rewind February 26, 2018

Early dermatology consultation linked to improved diagnostic accuracy and care in cellulitis

Long-term outcomes for off-pump and on-pump CABG are similar

Vegetation size greater than 10 mm associated with increased risk of mortality in infective endocarditis

License Our Award-Winning Physician-Written Medical News and Visual Abstracts

2 Minute Medicine is the leading authoritative medical news licensing service, and the only with reports written by practicing doctors.

LICENSE CONTENT

2MM+ Premium Access

No ads & unlimited access to all current reports, over 9000 searchable archived reports, visual abstracts, Weekly Rewinds, and the online edition of The Classics Series™ textbook.

Subscription Options
2 Minute Medicine

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Prior syncope presentation not associated with increased risk of motor vehicle collision
  • Baricitinib reduces mortality risk in patients hospitalized with COVID-19
  • Postoperative and nonoperative atrial fibrillation have a similar risk of associated thromboembolism
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.