Cerebral embolic protection does not decrease stroke incidence in TAVI patients
1. In this randomized trial, the use of cerebral embolic protection (CEP) did not decrease the 72-hour incidence of stroke...
Nerandomilast slows FVC decline in progressive pulmonary fibrosis
1. In this randomized controlled trial, treatment with nerandomilast led to slower declines in forced vital capacity (FVC) in patients...
Upadacitinib with glucocorticoids superior to glucocorticoids alone for giant cell arteritis remission
1. In this randomized trial, upadacitinib dosed at 15mg with a 26-week glucocorticoid taper showed superior efficacy than placebo with...
Oveporexton improves symptoms in patients with narcolepsy type 1
1. In this randomized controlled trial, oveporexton use significantly improved symptoms of narcolepsy over eight weeks. 2. Adverse events were...
Left atrial appendage closure is noninferior to oral anticoagulation after ablation for atrial fibrillation
1. In this randomized trial, left atrial appendage closure was associated with lower bleeding than oral anticoagulation in patients who...
Obinutuzumab plus standard therapy is efficacious in managing active lupus nephritis
1. In this randomized trial, obinutuzumab plus standard therapy was more efficacious than standard therapy alone in providing a complete...
Mepolizumab decreases exacerbations in patients with eosinophilic COPD
1. In this randomized controlled trial, mepolizumab decreased the annualized rate of moderate or severe exacerbations when added to triple...
Intensive blood pressure control reduces major cardiovascular event risk in type 2 diabetes patients
1. In this parallel design, randomized trial, intensive treatment of systolic blood pressure (SBP) resulted in a lower incidence of...
Lack of sentinel-lymph node biopsy does not alter survival in early invasive breast cancer
1. In this randomized, non-inferiority trial, the omission of surgical axillary staging was noninferior to sentinel lymph node biopsy in...
Adjunctive middle meningeal artery embolization superior to standard care in symptomatic chronic subdural hematomas
1. In this randomized controlled trial, middle meningeal artery embolization demonstrated a decreased risk of treatment failure in patients with...
