Oral nonstatin medication significantly lowers cholesterol in high-risk patients
1. In this randomized controlled trial, once-daily oral enlicitide was associated with sustained reductions in low-density lipoprotein cholesterol levels compared...
Sacituzumab govitecan plus pembrolizumab improves survival in advanced triple-negative breast cancer
1. Among patients with previously untreated programmed death-ligand 1 positive, triple-negative breast cancer, first-line sacituzumab govitecan plus pembrolizumab significantly prolonged...
Brain-penetrant enzyme replacement therapy improves biomarkers in mucopolysaccharidosis type II
1. In this open-label phase 1–2 study, pediatric patients with mucopolysaccharidosis type II treated with tividenofusp alfa showed substantial reductions...
One dose of human papillomavirus vaccine noninferior to two for preventing persistent infection
1. In a large randomized trial of adolescent girls, one dose of either the bivalent or nonavalent human papillomavirus (HPV)...
Nucleoside-modified mRNA influenza vaccine more effective than standard shot in adults
1. A nucleoside-modified mRNA (modRNA) influenza vaccine showed greater protection against influenza-like illness compared to a standard inactivated vaccine in...
Aficamten is superior to metoprolol in the management of obstructive hypertrophic cardiomyopathy
1. In this randomized trial, aficamten monotherapy led to greater improvements in exercise capacity compared to metoprolol in patients with...
An absence of cardiovascular risk factors is linked to over ten additional healthy years
1. In this large global cohort study, individuals aged 50 without five major cardiovascular risk factors (hypertension, hyperlipidemia, abnormal body...
Switching to camizestrant after ESR1 mutation detection prolongs progression free survival in advanced breast cancer
1. In patients with ER-positive, HER2-negative advanced breast cancer who developed an ESR1 mutation during first-line aromatase inhibitor plus CDK4/6...
AAV gene therapy shows durable benefit in hemophilia B
1. In this prospective cohort study, a single intravenous dose of scAAV2/8-LP1-hFIXco gene therapy in men with severe hemophilia B...
Second-line TAF-based ART improves viral suppression in pediatric HIV
1. In this randomized controlled trial (CHAPAS-4), tenofovir alafenamide fumarate (TAF) with emtricitabine showed superior viral suppression at 96 weeks...
