• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • Write for us
  • Contact us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Oncology

Captopril mitigates radiation-induced lung fibrosis in rats

byKhang DinhandAndrew Bishara
May 30, 2014
in Oncology
Reading Time: 3 mins read
0
Share on FacebookShare on Twitter

Image: PD

1. Captopril or the synthetic antioxidant, EUK-207, reduced functional, biochemical, and histopathological signs of lung fibrosis after whole thoracic radiation.

2. The combination of captopril and EUK-207 was incrementally superior at reducing fibrosis than either agent alone.

Evidence rating: 2 (Good)

Study Rundown: Radiation therapy is a mainstay in the treatment of lung cancer. Despite advances in technologies that have allowed radiation to be more precisely directed at tumors, normal lung tissue is also unavoidably irradiated. The result is inflammation and fibrosis that may lead to pneumonitis, which can be lethal. It has been shown that both antioxidants and angiotensin converting enzyme (ACE) inhibitors mitigate collateral toxicity to normal lung. In this study, the authors show that the synthetic antioxidant EUK-207 and captopril are effective in reducing functional, biochemical, and histopathological indicators of inflammation and fibrosis in rats that were irradiated. This study was limited by its short endpoint of 32 weeks. The authors also selected a species of rats that are especially prone to radiation-induced fibrosis, which may have biased the results to improvement with any agent. There was also no pharmacological control group.

Click to read the study in International Journal of Radiation Oncology

Relevant reading: Radiation damage to the lung: Mitigation by angiotensin-converting enzyme (ACE) inhibitors

RELATED REPORTS

#VisualAbstract: Obeticholic acid for the treatment of non-alcoholic steatohepatitis

Obeticholic acid for the treatment of non-alcoholic steatohepatitis

Adjuvant radiation decreases local recurrence in low-risk breast cancer

In Depth [Basic Science Study]: In this study, female SD rats were separated into six groups, consisting of eight rats each: untreated control, WTR alone, WTR and EUK-207, WTR and captopril, WTR and captopril plus EUK-207, or EUK-207 plus captopril without radiation. 11 Gy of radiation was delivered using an image-guided animal irradiator. From one week to 14 weeks post-irradiation, rats were treated according to their group design and then sacrificed at 32 weeks. Inflammation was estimated with 8-hydroxy-2-deoxyguanosine staining (8-OHdG), malonidaldehyde levels (MDA), and macrophage activation (ED-1). TGF-beta staining and hydroxyproline levels were used as proxy measures of fibrosis. At 32 weeks, the breathing rate for the WTR group and WTR + captopril plus EUK-207 group was 200 and 150, respectively (P<0.01). The relative expression of 8-OHdG for WTR group and WTR + captopril plus EUK-207 group were 15 and 7.3, respectively (P<0.01); MDA levels were 11 and 3, respectively (P<0.01); ED-1 were 7.5 and 4, respectively. Similarly, hydroxyproline levels for WTR group and WTR + captopril plus EUK-207 group were 160ug and 70ug, respectively (P<0.01), while TGF-beta relative expression was 43 and 10, respectively (P<0.01). For 8-OHdG and ED-1, the combined treatment group was superior to single therapy alone. Statistical analysis was performed using ANOVA and Tukey method of least-square means.

More from this author: Erlotinib does not demonstrate increased survival in ovarian epithelial carcinomas, Afatinib shows increased progression-free survival in non-small-cell lung cancer, Radiosurgery alone may be effective for some arteriovenous malformations, Escalated-dose radiotherapy did not increase survival in prostate cancer, Stereotactic radiosurgery promising for patients with multiple brain metastases

©2012-2014 2minutemedicine.com. All rights reserved. No works may be reproduced without expressed written consent from 2minutemedicine.com. Disclaimer: We present factual information directly from peer reviewed medical journals. No post should be construed as medical advice and is not intended as such by the authors, editors, staff or by 2minutemedicine.com. PLEASE SEE A HEALTHCARE PROVIDER IN YOUR AREA IF YOU SEEK MEDICAL ADVICE OF ANY SORT. 

Tags: antioxidantbasic science studycaptoprilfibrosislung radiationRadiation Oncologyrats
Previous Post

H1N1 vaccine likely safe for pregnant mothers

Next Post

Chemoembolization comparable to standard-of-care for small hepatocellular cancers

RelatedReports

#VisualAbstract: Obeticholic acid for the treatment of non-alcoholic steatohepatitis
StudyGraphics

#VisualAbstract: Obeticholic acid for the treatment of non-alcoholic steatohepatitis

January 8, 2020
Obeticholic acid for the treatment of non-alcoholic steatohepatitis
Gastroenterology

Obeticholic acid for the treatment of non-alcoholic steatohepatitis

December 23, 2019
Adjuvant radiation decreases local recurrence in low-risk breast cancer
Imaging and Intervention

Adjuvant radiation decreases local recurrence in low-risk breast cancer

January 23, 2015
Cranial radiotherapy associated with increased risk of anterior hypopituitarism
Endocrinology

Cranial radiotherapy associated with increased risk of anterior hypopituitarism

January 12, 2015
Next Post
Tumor size, chemoembolization response may predict hepatocellular carcinoma recurrence

Chemoembolization comparable to standard-of-care for small hepatocellular cancers

Combined lenalidomide and rituximab dose escalation found to be safe for CLL

Combined lenalidomide and rituximab dose escalation found to be safe for CLL

Low diastolic blood pressure associated with higher mortality in chronic kidney disease

Overall improvement in management of high blood pressure between 1994 and 2011

License Our Award-Winning Physician-Written Medical News and Visual Abstracts

2 Minute Medicine is the leading authoritative medical news licensing service, and the only with reports written by practicing doctors.

LICENSE CONTENT

Get 2MM+ Premium Access

No ads & unlimited access to all current reports, over 9000 searchable archived reports, visual abstracts, Weekly Rewinds, and the online edition of The Classics Series™ textbook.

Subscription Options
2 Minute Medicine

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • #VisualAbstract: Bimekizumab shows a favourable 2-year safety profile in patients with moderate to severe plaque psoriasis
  • Medical cannabis provides little improvement to sleep in chronic pain patients
  • Alzheimer disease in individuals with Down syndrome has similar variability in age of onset and mortality rate as autosomal dominant forms
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.