Patient lacking apolipoprotein E has altered lipid metabolism without neurocognitive or visual defects
1. Complete lack of endogenous Apolipoprotein E (apoE) was associated with altered lipid metabolism, including high cholesterol.2. Lack of apoE was not associated with...
No increased overall risk of systemic events with use of anti-VEGF eye treatments
1. There was no overall increase in systemic cardiovascular events with the use of antibodies to vascular endothelial growth factor (anti-VEGF) therapies in the...
Functional decline in children with retinoblastoma greater than expected
1. A significant decline in developmental functioning was seen in children treated for retinoblastoma after age 5 years. 2. The greatest decline in cognitive functioning...
Non-ophthalmologists diagnose CMV retinitis with reasonable accuracy
1. For non-experts, sensitivity in diagnosing CMV retinitis ranged from 64.0% to 95.5% and specificity ranged from 65.6% to 92.5%.2. When compared to the expert consensus as...
Steroid implant may improve diabetic macular edema
1. Both the 0.35mg and 0.7mg dexamethasone dosing led to a significant increase in visual acuity compared to sham.2. Central retinal thickness, a measure...
Environmental exposure associated with increased risk of exfoliative glaucoma
Image: PD1. A significant association was observed with patients who were exposed to the outdoors for over 11 hours during the high school to...
Vasodilators associated with increased risk of age-related macular degeneration
Image: PD1. After adjustments, use of vasodilators or ß-blockers were significantly associated with increased risk of early and late age-related macular degeneration (AMD), respectively.2. In particular, oral nitroglycerin...
Key factors for non-response to ranibizumab in macular degeneration identified
Image: PD 1. Fibrovascular pigment epithelial detachment (PED) and serous PED were associated with non-response to intravitreal ranibizumab treatment as determined by visual acuity testing. 2....
TGF-β1 polymorphism may protect against diabetic retinopathy
Image: PD 1. The +869T/C(L10P) gene polymorphism of TGF-β1 was significantly associated with decreased susceptibility to diabetic retinopathy. 2. The -509C/T polymorphism in the TGF-β1 gene...
Systemic beta-blockers and nitrates linked to lower intraocular pressure
Image: PD1. Both ß-blockers (-0.92 mmHg, p<0.001) and nitrates (-0.63 mmHg, p=0.011) were associated with a significantly lower intraocular pressure.2. Statins and aspirin were...
