ACKR1 variant increases risk of azathioprine-related hematopoietic toxicity
1. Patients with the ACKR1 variant (CC genotype) had an elevated risk of azathioprine discontinuation attributed to hematopoietic toxicity. 2....
Rheumatology
Incidence of Kawasaki disease found to be lower during the COVID-19 pandemic in the United States
1. This multicenter cohort study of 3922 children with Kawasaki disease (KD) demonstrated that there was a 28.2% decline in...
Upadacitinib significantly improves clinical remission rate for moderately to severely active ulcerative colitis
1. Upadacitinib led to significantly greater percentages of clinical remission compared to placebo for both induction and maintenance studies. 2....
Subcutaneous risankizumab maintenance therapy superior to placebo for moderate-severe Crohn’s disease
1. Compared to a placebo (withdrawal) group, patients maintained on subcutaneous risankizumab had greater rates of clinical remission. 2. Adverse...
Risankizumab induction therapy is effective for moderate-to-severe Crohn’s disease
1. The risankizumab group showed greater clinical remission and endoscopic response rates compared to placebo across the ADVANCE and MOTIVATE...
Oral tacrolimus noninferior to intravenous cyclophosphamide for lupus nephritis
1. Oral tacrolimus was noninferior to intravenous cyclophosphamide for lupus nephritis disease measures with lower toxicity. Evidence Rating Level: 1...
Rilzabrutinib demonstrates rapid and durable clinical activity for immune thrombocytopenia
1. Rilzabrutinib was active and 400mg twice daily was identified as the dose for further testing with low-level toxic effects....
Prenatal exposure to maternal autoimmune diseases associated with increased risks of mental disorders in offspring
1. In utero exposure to any maternal autoimmune disease was associated with increased risks of overall and type-specific mental disorders...
Initiation of targeted disease-modifying antirheumatic drugs in patients with rheumatoid arthritis not associated with reduced risk of Alzheimer disease and related dementia
1. There were no differences in the risk of Alzheimer disease and related dementia in patients with rheumatoid arthritis treated...
Donidalorsen reduces attacks in patients with C1 inhibitor deficiency
1. Patients with hereditary angioedema receiving donidalorsen showed reduced rates of angioedema attacks compared to patients receiving placebo treatment. 2....
