• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • Write for us
  • Contact us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Cardiology

Everolimus only protects against early cardiac allograft vasculopathy

bys25qthea
April 11, 2013
in Cardiology, Chronic Disease, Surgery
Reading Time: 2 mins read
0
Share on FacebookShare on Twitter

Image: PD

1. Everolimus treatment is associated with a lower maximal intimal thickness (MIT) increase during first year (OR=0.14, p=.02). 

2. High dose statins have an independently protective effect on MIT increase in early and late cardiac allograft vasculopathy (CAV). 

3. Higher triglyceride levels at baseline are associated with higher late CAV progression. 

Evidence Rating Level: 2 (Good) 

Study Rundown: The data in this observational study suggest that everolimus is effective at limiting the progression of early CAV (< 1 year), but not for late CAV (< 5 years).  Meanwhile, high-dose statins seem to be protective of both early and late CAV.  This information is useful because MIT progression within the first year has been directly tied to the prognosis of heart transplant patients, with lower MIT progression improving prognosis.   One limitation of this study is that it was not randomized, and as an observational trial there are confounding factors that may be difficult to take into account.  Moreover, as the associations between late MIT progression and prognosis after heart transplant are not yet fully known, more research has to be done before the full impacts of everolimus long-term can be understood.

Click to read the study in American Journal of Transplantation

RELATED REPORTS

Methamphetamine use associated with cardiovascular disease in hospitalized patients

Management of uncomplicated urinary tract infections amongst women in the United States Military Health System highly concordant with guidelines

Gout flares associated with a transient increase in subsequent risk of cardiovascular events

Relevant Reading: From clinical trials to clinical practice: an overview of Certican (everolimus) in heart transplantation.

In-Depth [retrospective cohort]: 143 heart transplant patients were divided into early and late cohorts with 91 and 52 patients each, respectively.  Patients differed in their treatment protocol, with some receiving everolimus and the control group receiving mycophenolate mofetil (MMF).  The early cohort had their 3-6 week and 1 year post-operative intravascular ultrasound (IVUS) evaluated and the late cohort had the 1 year and 5 year IVUS evaluated. Evaluation focused on the measurement of maximal intimal thickness (MIT), which shows the progression of cardiac allograft vasculopathy.  MIT changed less under everolimus than MMF during the first year (0.23 vs 0.37 mm, p=.05).  In patients with high-dose vs. low-dose statins within the first year, progression of MIT was also delayed (0.23 vs. 0.38, p=0.01).  High dose statins continued to be more effective in preventing development of late CAV at the 5 year mark (10% vs. 39%, p=0.02).  Finally, patients with late CAV had higher median triglycerides as recorded at baseline than those without late CAV (210 vs. 153, p=0.01).

By David Mattos and Allen Ho

© 2013 2minutemedicine.com. All rights reserved. No works may be reproduced without written consent from 2minutemedicine.com. Disclaimer: We present factual information directly from peer reviewed medical journals. No post should be construed as medical advice and is not intended as such by the authors or by 2minutemedicine.com. PLEASE SEE A HEALTHCARE PROVIDER IN YOUR AREA IF YOU SEEK MEDICAL ADVICE OF ANY SORT. Content is produced in accordance with fair use copyrights solely and strictly for the purpose of teaching, news and criticism. No benefit, monetary or otherwise, is realized by any participants or the owner of this domain. 

 

Previous Post

BRAF V600E mutations linked with increased mortality in thyroid cancer

Next Post

Chronic exertional compartment syndrome prevalent in the military population

RelatedReports

Carbon nanotubes ameliorate methamphetamine addiction in mice [PreClinical]
Cardiology

Methamphetamine use associated with cardiovascular disease in hospitalized patients

August 8, 2022
Implementation of pneumococcal vaccine programs linked to decreased antibiotic prescription
Infectious Disease

Management of uncomplicated urinary tract infections amongst women in the United States Military Health System highly concordant with guidelines

August 8, 2022
Increased diabetes risk observed in gout patients
Cardiology

Gout flares associated with a transient increase in subsequent risk of cardiovascular events

August 8, 2022
Multidrug induction therapy increases remission from lupus nephritis
Chronic Disease

Litifilimab associated with reduced disease severity in patients with cutaneous lupus erythematosus

August 8, 2022
Next Post
Chronic exertional compartment syndrome prevalent in the military population

Chronic exertional compartment syndrome prevalent in the military population

Home visits in Ghana improve neonatal mortality

Home visits in Ghana improve neonatal mortality

IUD contraception equally safe in teenagers as in older women

IUD contraception equally safe in teenagers as in older women

License Our Award-Winning Physician-Written Medical News and Visual Abstracts

2 Minute Medicine is the leading authoritative medical news licensing service, and the only with reports written by practicing doctors.

LICENSE CONTENT

2MM+ Premium Access

No ads & unlimited access to all current reports, over 9000 searchable archived reports, visual abstracts, Weekly Rewinds, and the online edition of The Classics Series™ textbook.

Subscription Options
2 Minute Medicine

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Methamphetamine use associated with cardiovascular disease in hospitalized patients
  • Management of uncomplicated urinary tract infections amongst women in the United States Military Health System highly concordant with guidelines
  • Gout flares associated with a transient increase in subsequent risk of cardiovascular events
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.