• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • Write for us
  • Contact us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Chronic Disease

Long term phototherapy can enhance treatment response in vitiligo

byAnees DaudandLauren Ko
April 7, 2017
in Chronic Disease, Dermatology
Reading Time: 2 mins read
0
Share on FacebookShare on Twitter

1. Examination of prospective studies found that a majority of patients with vitiligo had at least 25% re-pigmentation in response to phototherapy, with rates increasing with longer durations of treatment.

2. Subgroup analysis revealed marked repigmentation on the face and neck in patients receiving at least 6 months of narrow band UV-B (NBUVB) phototherapy.

Evidence Rating Level: 2 (Good)       

Study Rundown: Vitiligo is a common chronic depigmentation disorder which has no definitive cure. Phototherapy, including both narrowband UV-B (NVUVB) and psoralen-UV-A (PUVA), has long been a mainstay of therapy for generalized disease. This systematic review and meta-analysis analyzed 35 prospective studies to quantify the benefit of phototherapy in patients with vitiligo. The primary outcome was re-pigmentation rate, and was classified as mild (≥25%), moderate (≥50%), or marked (≥75%).

The results suggested that longer treatments of phototherapy enhanced treatment response in generalized vitiligo patients. Subgroup analysis indicated that marked re-pigmentation occurred specifically on the face and neck with long term NBUVB phototherapy. This study, as with all systematic reviews, was limited by the heterogeneity of its patients and of the studies included for analysis. Further, quantifying re-pigmentation on a quartile scale was arbitrary and may not be a good measure of successful vitiligo management. However, the authors only included prospective studies with high quality of evidence, thus contributing to the study’s overall strength.

Click to read the study, published in JAMA Dermatology

Relevant Reading: Vitiligo: a comprehensive overview, part II: treatment options and approach to treatment.

RELATED REPORTS

#VisualAbstract: Systematic review shows a lack of high-quality evidence on the association between UV exposure and keratinocyte carcinoma development in skin of colour

Phototherapy not associated with increased risk of childhood cancer

2 Minute Medicine Rewind November 1, 2021

In-Depth [systematic review and meta-analysis]: This study analyzed 35 studies including 1428 unique patients in order to determine how NVUVB and PUVA phototherapy influenced treatment response in vitiligo. In response to NVUVB therapy, mild re-pigmentation was observed in 62.1-75% of patients, moderate re-pigmentation was seen in 31.1-56.8% of patients, and marked re-pigmentation was observed in 13-35.7%, with rates increasing with longer study follow up period. Subgroup analysis revealed that marked responses were achieved face and neck for patients undergoing at least 6 months of NVUVB (95%CI 24.2%-64.2%), especially as compared to the trunk (26.1%, 95%CI 8.7-43.5%), extremities (17.3%, 95%CI 8.2-26.5%), and hands and feet (0). At six month and 12 month follow up periods following treatment with PUVA therapy, mild re-pigmentation was observed in 51.4 and 61.6% of patients, moderate re-pigmentation was seen in 23.5 and 34.3% of patients, and marked re-pigmentation was observed in 8.5 and 13.6%, respectively. This analysis of prospective studies suggested that longer treatment durations of phototherapy should be encouraged to improve treatment response to vitiligo. Further, re-pigmentation rates were higher with NVUVB phototherapy compared to those following PUVA phototherapy.

Image: CC/Wiki

©2017 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

Tags: phototherapyvitiligo
Previous Post

Weight fluctuations associated with mortality in patients with coronary artery disease

Next Post

Transcatheter aortic valve replacement noninferior to surgery for intermediate-risk patients: The SURTAVI trial

RelatedReports

#VisualAbstract: Systematic review shows a lack of high-quality evidence on the association between UV exposure and keratinocyte carcinoma development in skin of colour
StudyGraphics

#VisualAbstract: Systematic review shows a lack of high-quality evidence on the association between UV exposure and keratinocyte carcinoma development in skin of colour

March 31, 2022
Poverty, preterm birth demonstrate additive effect on cognition
Chronic Disease

Phototherapy not associated with increased risk of childhood cancer

November 3, 2021
Novel coronavirus identified from patients with pneumonia in Wuhan, China
Weekly Rewinds

2 Minute Medicine Rewind November 1, 2021

November 1, 2021
Confounding influences phototherapy’s association with increased childhood cancer risk
Oncology

Confounding influences phototherapy’s association with increased childhood cancer risk

May 23, 2016
Next Post
Cerebral protection device effective in patients undergoing transcatheter aortic valve implantation

Transcatheter aortic valve replacement noninferior to surgery for intermediate-risk patients: The SURTAVI trial

Epidural corticosteroid injections provide only short-term radiculopathy pain relief

Interactive voice response system effective for CBT-based therapy for chronic back pain

Attenuation values may help differentiate renal neoplasm from simple cyst on contrast-enhanced CT

Attenuation values may help differentiate renal neoplasm from simple cyst on contrast-enhanced CT

License Our Award-Winning Physician-Written Medical News and Visual Abstracts

2 Minute Medicine is the leading authoritative medical news licensing service, and the only with reports written by practicing doctors.

LICENSE CONTENT

2MM+ Premium Access

No ads & unlimited access to all current reports, over 9000 searchable archived reports, visual abstracts, Weekly Rewinds, and the online edition of The Classics Series™ textbook.

Subscription Options
2 Minute Medicine

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Sickle cell trait associated with preexisting kidney comorbidities and increased COVID-19 mortality
  • Adding atezolizumab to standard of care treatment for human epidermal growth factor receptor 2 (HER2) positive early breast cancer does not improve pathologic response outcomes
  • FOLFOX combined with nivolumab and trastuzumab in ERBB2-positive esophagogastric adenocarcinoma is an emerging therapy option
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.