• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • 2MM Podcast
  • Write for us
  • Contact Us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Obstetrics

[Physician Comment] Most perinatal outcomes similar between Hispanic and non-Hispanic white women with mild gestational diabetes

bys25qthea
November 17, 2012
in Obstetrics
Reading Time: 4 mins read
0
Share on FacebookShare on Twitter

Image: CC/Flickr

Study author Dr. Erica Berggren, talks to 2 Minute Medicine: Maternal Fetal Medicine Specialist at Jefferson Medical College

“Our findings of minimal differences by race/ethnicity is clinically relevant, as our data do not support tailored diagnostic criteria or treatment for Hispanic women, among women with mild hyperglycemia.”

Key study points: 

1. Poor glycemic control in gestational diabetes is associated with adverse maternal and fetal outcomes.

2. Across treatment groups, Hispanic and non-Hispanic groups experienced very similar perinatal outcomes.

RELATED REPORTS

Sodium-glucose cotransporter 2 inhibitors may decrease risk of serious liver events in patients with cirrhosis

#VisualAbstract: Lactated Ringer’s Solution Does Not Improve Outcomes Relative to Normal Saline

2MM: AI Roundup – FDA’s AI Push, Trial Speedups with Real-World Data, Smart Surgical Monitors, and Regulatory Overhaul Begins [July 2nd, 2025]

Primer: Pregnancy is a state of increased insulin resistance, owing to high estrogen and various placental hormones (cortisol, placental growth hormone, progesterone, etc) and peaks in the third trimester. However, some pregnant women go on to develop glucose intolerance or gestational diabetes (GDM). Certain demographic groups (e.g. overweight, obese and Hispanic women) are at higher risk for developing GDM (1-2).

In women with GDM, poor glucose control increases risk for both adverse maternal and fetal outcomes. Women with GDM are more likely to develop hypertensive disorders of pregnancy (e.g. gestational hypertension, pre-eclampsia, eclampsia) and their fetuses are more likely to be macrosomic, increasing their risk for hyperbilirubinemia and birth trauma (3).

Customary screening in the U.S. is to perform the 50-gram 1-hour oral glucose challenge test at 24-28 weeks gestation. Blood glucose values greater than 135mg/dL suggest glucose intolerance and values greater than 200mg/dL concern for frank diabetes. Women with abnormal screening tests will undergo the 100-gram 3-hour oral glucose tolerance test (OGTT), with a positive result defined as at least two blood glucose values taken at 1-hour increments (fasting, 1-hour, 2-hour, 2-hour) that exceed threshold values (Table 1) (1).

Table 1. Two diagnostic criteria for the OGTT to diagnose GDM

Status

Plasma Glucose Level

(Carpenter/Coustan Conversion)

Plasma Glucose Level

(National Diabetes Data Group)

mg/dL

mmol/L

mg/dL

mmol/L

Fasting

95

5.3

105

5.8

One hour

180

10.0

190

10.6

Two hours

155

8.6

165

9.2

Three hours

140

7.8

145

8.0

    Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care 2000;23(suppl 1):S4–S19.

Hispanic women are at higher risk for GDM, but it remains unknown whether perinatal outcomes among Hispanic women with glucose intolerance or GDM differ from those in non-Hispanic women. The present work addressed this question by comparing perinatal outcomes between Hispanic and non-Hispanic white women with glucose intolerance or mild GDM.

Background reading: 

1. ACOG’s FAQ on gestational diabetes

2. Up-to-date: Screening and diagnosis of diabetes mellitus during pregnancy

3. Gestational Diabetes. ACOG Practice Bulletin No. 30. American College of Obstetricians and Gynecologists. Obstet Gynecol 2001;98:525–538

This [secondary analysis of a randomized clinical trial] compared perinatal outcomes in women with glucose intolerance or mild gestational diabetes mellitus by ethnicity/racial group (Hispanic or non-Hispanic women).

Among women with glucose intolerance, Hispanic women had increased odds of having a neonate with elevated C-cord peptide (a marker of fetal insulinemia) (OR 1.79, CI: 1.04-3.08) and neonatal hypoglycemia (OR 2.04 CI 1.18-3.53). In women with mild GDM randomized to no treatment, outcomes were similar. In women with mild GDM randomized to treatment, Hispanic women were at increased odds of having a neonate with hyperinsulinemia (OR 2.96, CI 1.33-6.60).

In sum: Most perinatal outcomes were similar between Hispanic and non-Hispanic ethnic groups with glucose intolerance or mild gestational diabetes. To conclude that outcomes differ by ethnicity, we would expect a number of related markers to manifest this difference (e.g. fetal hypoglycemia, hyperinsulinemia and high c-cord peptide). Thus, it is likely that the individual differences observed are not representative of a clinically meaningful difference in perinatal outcomes by ethnicity.

Click to read this article in the current issue of Obstetrics & Gynecology

By [LH]

More from this author: Pelvic strength after childbirth, Robot-assisted myomectomy, Predicting menopause with rate of change of AMH

© 2012 2minutemedicine.com. All rights reserved. No works may be reproduced without written consent from 2minutemedicine.com. DISCLAIMER: Posts are not medical advice and are not intended as such. Please see a healthcare professional if you seek medical advice.

Previous Post

[Researcher Comment] UK research funding for infectious diseases inconsistent with global burden of disease

Next Post

[Featured] Elevated systolic blood pressure linked to white matter brain damage in young adults

RelatedReports

Low free sugar diet reduces hepatic steatosis in nonalcoholic fatty liver disease in adolescent males
Chronic Disease

Sodium-glucose cotransporter 2 inhibitors may decrease risk of serious liver events in patients with cirrhosis

July 2, 2025
#VisualAbstract: Lactated Ringer’s Solution Does Not Improve Outcomes Relative to Normal Saline
StudyGraphics

#VisualAbstract: Lactated Ringer’s Solution Does Not Improve Outcomes Relative to Normal Saline

July 2, 2025
2MM: AI Roundup- AI Cancer Test, Smarter Hospitals, Faster Drug Discovery, and Mental Health Tech [May 2nd, 2025]
AI Roundup

2MM: AI Roundup – FDA’s AI Push, Trial Speedups with Real-World Data, Smart Surgical Monitors, and Regulatory Overhaul Begins [July 2nd, 2025]

July 2, 2025
The Scan by 2 Minute Medicine®:  Ultra-Trail du Mont-Blanc, Taylor Swift, NBA rookie Chet Holmgren and Magic Mushrooms!
The Scan by 2 Minute Medicine®

The Scan by 2 Minute Medicine®: Celebrity diagnoses spur screenings, athlete mental-health push, reality-TV heart lesson, and a sitcom PSA wave

July 2, 2025
Next Post

[Featured] Elevated systolic blood pressure linked to white matter brain damage in young adults

[Physician Comment] Children born to mothers with depression have more behavioral problems; depression meds in pregnancy not definitively linked with childhood neurodevelopment

[Physician Comment] Statins associated with reduced mortality in pneumonia-related hospitalizations

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Sodium-glucose cotransporter 2 inhibitors may decrease risk of serious liver events in patients with cirrhosis
  • #VisualAbstract: Lactated Ringer’s Solution Does Not Improve Outcomes Relative to Normal Saline
  • 2MM: AI Roundup – FDA’s AI Push, Trial Speedups with Real-World Data, Smart Surgical Monitors, and Regulatory Overhaul Begins [July 2nd, 2025]
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
No Result
View All Result

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.