• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • Write for us
  • Contact us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Gastroenterology

Nivolumab in resected esophageal or gastroesophageal junction cancer improved survival

byAvneesh BhanguandHarsh Shah
April 5, 2021
in Gastroenterology, Oncology
Reading Time: 2 mins read
0
Share on FacebookShare on Twitter

1. Adjuvant nivolumab significantly improved disease-free survival compared to placebo among patients with resected esophageal or gastroesophageal junction cancer.

2. Adverse events were more common in the nivolumab group compared to the placebo group.

Evidence Rating Level: 1 (Excellent)    

Study Rundown: Neoadjuvant chemotherapy followed by surgery and surveillance is the current standard of care treatment for resectable, locally advanced esophageal or gastroesophageal junction cancer. There remains a high level of recurrence of disease post-treatment, suggesting the need for adjuvant therapy. Nivolumab, a monoclonal anti-programmed death 1 (PD-1) antibody, has been shown to improve survival in this patient population in previous trials. This study evaluated the use of nivolumab as adjuvant treatment in patients with esophageal or gastroesophageal junction cancer who received neoadjuvant chemotherapy and surgery. Treatment with nivolumab, compared to placebo, led to improved disease-free survival. In addition to a disease-free survival benefit, nivolumab treatment resulted in improved distant metastasis-free survival; however, adverse events were more common in the nivolumab group compared to the placebo group. Study limitations include relatively small sample size, underrepresentation of racial minority patients, and lack of reporting on long-term outcomes. Nonetheless, this study’s results are significant in using nivolumab as effective adjuvant therapy in patients with resectable, locally advanced esophageal or gastroesophageal junction cancer.

Click to read the study in NEJM

Relevant Reading: Nivolumab in patients with advanced gastric or gastro-oesophageal junction cancer refractory to, or intolerant of, at least two previous chemotherapy regimens (ONO-4538-12, ATTRACTION-2): a randomised, double-blind, placebo-controlled, phase 3 trial

In-Depth [randomized controlled trial]: This randomized control trial enrolled 794 patients across 170 sites and 29 countries. Patients 18 years or older who had resected esophageal or gastroesophageal junction cancer and received neoadjuvant chemoradiation therapy were included in the study. Patients diagnosed with stage I esophageal or gastroesophageal junction cancer were excluded from the study. The patients were randomized in a 2:1 ratio to receive nivolumab or placebo, respectively. The primary endpoint was disease-free survival defined as the time from randomization to the first date of disease recurrence or death. Median disease-free survival was 22.4 months (95% confidence interval [CI], 16.6 to 34.0) in the nivolumab group compared to 11.0 months (95% CI, 8.3 to 14.3) in the placebo group (hazard ratio for disease recurrence or death, 0.69; 96.4% CI, 0.56 to 0.86; P<0.001). Furthermore, the risk of distant recurrence or death was 26% lower when treated with nivolumab compared to placebo (hazard ratio 0.74; 95% CI, 0.60 to 0.92). Adverse events were more common with nivolumab than placebo, including grade 3 or 4 events (nivolumab group, 13%; placebo group, 6%). Altogether, this trial showed in patients with resectable, locally advanced esophageal or gastroesophageal junction cancer, nivolumab therapy led to improved disease-free survival compared to placebo.

RELATED REPORTS

#VisualAbstract: Second-line immunosuppression associated with worse outcomes for immune-related adverse events in melanoma

#VisualAbstract: Nivolumab plus ipilimumab improves recurrence-free survival in patients with resected advanced melanoma

Nivolumab plus ipilimumab improves recurrence-free survival in patients with resected advanced melanoma

Image: PD

©2021 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

Tags: esophageal cancergastroesophageal junction cancerNivolumab
Previous Post

Ponesimod may be superior to teriflunomide for relapsing multiple scleorsis

Next Post

Tenofovir alafenamide associated with metabolic complications in patients with HIV

RelatedReports

#VisualAbstract: Second-line immunosuppression associated with worse outcomes for immune-related adverse events in melanoma
StudyGraphics

#VisualAbstract: Second-line immunosuppression associated with worse outcomes for immune-related adverse events in melanoma

November 17, 2022
#VisualAbstract: Pembrolizumab provides survival benefit in PD-L1 positive advanced head and neck cancer
StudyGraphics

#VisualAbstract: Nivolumab plus ipilimumab improves recurrence-free survival in patients with resected advanced melanoma

October 20, 2022
Adding sargramostim to ipilimumab may improve survival in advanced melanoma
Chronic Disease

Nivolumab plus ipilimumab improves recurrence-free survival in patients with resected advanced melanoma

October 12, 2022
PD-1 blocker pembrolizumab may be a promising therapy for advanced Merkel-cell carcinoma
Chronic Disease

Stereotactic body radiation does not improve outcomes in patients with advanced Merkel cell carcinoma receiving nivolumab and ipilimumab

October 7, 2022
Next Post

Tenofovir alafenamide associated with metabolic complications in patients with HIV

#VisualAbstract: Azithromycin does not improve clinical outcomes in high-risk patients with suspected COVID-19 in the community setting

#VisualAbstract: Direct oral anticoagulants may be the superior treatment for patients with atrial fibrillation on dialysis

Noninvasive imaging method detects and evaluates size of metastases

Celecoxib added to adjuvant chemotherapy does not improve survival or recurrence versus placebo in stage III colon cancer

License Our Award-Winning Physician-Written Medical News and Visual Abstracts

2 Minute Medicine is the leading authoritative medical news licensing service, and the only with reports written by practicing doctors.

LICENSE CONTENT

2MM+ Premium Access

No ads & unlimited access to all current reports, over 9000 searchable archived reports, visual abstracts, Weekly Rewinds, and the online edition of The Classics Series™ textbook.

Subscription Options
2 Minute Medicine

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • BNT162b2 booster is safe and reduces COVID-19 transmission in older adults
  • Bisphosphonates, denosumab, abaloparatide, teriparatide, and romosozumab reduce postmenopausal fracture risk
  • Epstein-Barr viral load monitoring reduces risk of post-liver transplant lymphoproliferative disease
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

Want more physician-written
medical news?

Join over 10 million yearly readers and numerous companies. For healthcare professionals
and the public.

Subscribe for free today!

Subscription options