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Home All Specialties Pulmonology

Oral appliances ineffective for daytime sleepiness in mild/moderate obstructive sleep apnea

byAshley AaroeandJames Jiang
June 2, 2015
in Pulmonology
Reading Time: 3 mins read
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1. Custom-made oral appliances reduced episodes of sleep apnea, snoring, and restless legs symptoms in patients with daytime sleepiness and snoring or mild to moderate obstructive sleep apnea (OSA).

2. Oral appliances did not improve daytime sleepiness or quality of life versus a placebo appliance in this population.

Evidence Rating Level: 1 (Excellent)

Study Rundown: Obstructive sleep apnea (OSA) is a sleep disorder in which upper airway obstruction leads to periods of paused breathing during sleep. It can result in diminished quality of life for patients, as they experience symptoms including daytime sleepiness, headaches, and restless legs. Previous studies have established a benefit of custom-fitted oral appliances designed to draw the mandible forward and open the airway in moderate to severe OSA, chiefly in reducing the number of apneic events during the night. The authors of this study sought to investigate whether or not there was a benefit of using such appliances in mild to moderate OSA with regard to quality of life and degree of excess daytime sleepiness.

Oral appliance therapy was not associated with improvements in daytime sleepiness at 4 months follow-up when compared with a placebo intraoral device. However, complaints of restless legs symptoms (described as an urgent need to move the legs) were significantly reduced. Strengths of this study include its design, as a randomized and placebo-controlled trial, as well as the fact that over the study duration there was fairly minimal drop-out and high compliance in both arms. The study was also well powered, though the study sample was slightly smaller than the authors intended.

Click to read the study, published today in JAMA Internal Medicine

Relevant Reading: Review of oral appliances for treatment of sleep-disordered breathing

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In-Depth [randomized controlled trial]: Patients seen at Umea University, in Sweden, who reported snoring to physicians, and were referred to orthodontists for oral appliances were asked to participate in this study. Patients who snored, had daytime sleepiness, and had mild to moderate sleep apnea were included. Exclusion criteria included tonsillar hypertrophy, severe dementia, occupational drivers, and biased patients. Patients underwent single-blinded randomization to receive either an adjustable oral appliance for sleep apnea, or a placebo intraoral device for a four-month study period. Intervention devices were fitted plaster casts that on average moved the lower jaw forward a mean of 6.8 mm. The placebo device did not result in any advancement of the mandible.

Sleepiness was assessed via Epworth Sleepiness Scale (ESS) and the Karolinska Sleepiness Scale (KSS) as subjective measurements, and the Oxford Sleep Resistance Test (OSLER) as an objective measurement of daytime sleep latency. The Short-Form 36-item Health Survey was used to assess quality of life. Polysomnography was performed to assess episodes of sleep apnea. 91 patients completed the study between 2007 and 2011. The mean time before follow-up was 175 days. There was no improvement in daytime sleepiness, with the intervention group ESS >10 in 53% of patients at baseline, to 24% at follow-up for the oral appliance group. The placebo group had ESS >10 in 54% of patients at baseline, to 40% at follow (p = 0.11). The KSS and OSLER data echoed this finding. The SF-36 survey did not differ between placebo or device groups in any domain. Snoring was less frequent in the device group versus placebo (p < 0.001), as was presence of restless leg symptoms (p = 0.02).

Image: PD

©2015 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

Tags: Obstructive Sleep Apnea
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