• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • 2MM Podcast
  • Write for us
  • Contact Us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan+
  • Wellness
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Career
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan+
  • Wellness
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Career
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Chronic Disease

Parathyroidectomy associated with a reduction in fracture risk among adults with primary hyperparathyroidism

byJake EngelandMichael Pratte
December 6, 2021
in Chronic Disease, Endocrinology, Surgery
Reading Time: 2 mins read
0
Share on FacebookShare on Twitter

1. This large, population-based cohort study demonstrated that adults with primary hyperparathyroidism who underwent parathyroidectomy within one year of diagnosis had reduced risk of any site fracture and hip fracture compared to those who managed nonoperatively.

Evidence Rating Level: 2 (Good)

Study Rundown: Primary hyperparathyroidism (PHPT) is associated with a higher risk of fractures. A previous study demonstrated that parathyroidectomy in patients with PHPT reduces fracture risk compared to observation or medical treatment; however, due to some critical limitations from the study, the results could not be used on their own to guide management decisions. This population-based, longitudinal cohort study of Medicare beneficiaries diagnosed with PHPT (210 206 participants) from January 1, 2006, until December 31, 2017, investigated whether parathyroidectomy in older adults with PHPT is independently associated with decreased clinical fracture risk. Patients were defined as the parathyroidectomy treatment group if they received a parathyroidectomy within one year of diagnosis; the remainder of patients with PHPT were defined as the nonoperative cohort. The primary outcome was the incidence of clinical fracture at any site, and the secondary outcome was the incidence of hip fracture. Among all included participants in the study, 30% received parathyroidectomy within the first year of diagnosis. Among 63 136 parathyroidectomy patients, 6447 (10.2%) developed a fracture compared to 20 076/147 070 (13.7%) in the nonoperative cohort. There was a reduced adjusted risk of any clinical fracture (hazard ratio [HR]: 0.78 [95% CI: 0.76-0.80]) and hip fracture (HR: 0.76 [95% CI: 0.72-0.79]) in parathyroidectomy patients compared to nonoperative patients. The reduction in risk of fractures remained statistically significant after controlling for age, sex, osteoporosis, frailty, and even those who did not meet operative guidelines. Recurrent laryngeal nerve injury was rare among patients who received parathyroidectomy (0.99%). Overall, parathyroidectomy treatment for older adults diagnosed with PHPT was strongly associated with a lower risk of any clinical fracture; therefore, surgery in this population deserves more consideration to reduce disability. This study included a large, national cohort of adults with PHPT increasing the likelihood of generalizing it to other populations. One limitation of this study, however, is the lack of data in Medicare regarding the severity of PHPT and baseline bone mineral density data, which could have resulted in selection bias for those who received parathyroidectomies.

Click to read the study in JAMA Internal Medicine

Click to read an accompanying editorial in JAMA Internal Medicine

Relevant Reading: The relationship of parathyroidectomy and bisphosphonates with fracture risk in primary hyperparathyroidism: an observational study

RELATED REPORTS

Parathyroidectomy does not impact renal function in adults with primary hyperparathyroidism

Primary hyperparathyroidism associated with an increased risk of fractures and cardiovascular events

Ultrasound-guided microwave ablation may be effective in severe secondary hyperparathyroidism

Image: PD

©2021 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

Tags: hyperparathyroidismsecondary hyperparathyroidism
Previous Post

Maternal sexually transmitted infections associated with increased risk of preterm birth

Next Post

Smelling and tasting milk alongside tube feeding does not improve weight in preterm infants

RelatedReports

Forearm parathyroid reimplantation may be effective in preventing hypoparathyroidism
Endocrinology

Parathyroidectomy does not impact renal function in adults with primary hyperparathyroidism

April 21, 2023
Forearm parathyroid reimplantation may be effective in preventing hypoparathyroidism
Chronic Disease

Primary hyperparathyroidism associated with an increased risk of fractures and cardiovascular events

June 13, 2022
Ultrasound-guided microwave ablation may be effective in severe secondary hyperparathyroidism
Endocrinology

Ultrasound-guided microwave ablation may be effective in severe secondary hyperparathyroidism

February 13, 2017
Next Post
Head circumference better predicts labor dystocia than weight

Smelling and tasting milk alongside tube feeding does not improve weight in preterm infants

Quick Take: Functional Outcome of Intravenous Thrombolysis in Patients With Lacunar Infarcts in the WAKE-UP Trial

Intraventricular alteplase use associated with a minimal reduction in parenchymal intracerebral hemorrhage volume in patients with intracerebral hemorrhage and intraventricular hemorrhage

Pediatric palliative care outcome measures often miss quality of life

Tofacitinib reduces the rate of flare-ups in patients with polyarticular juvenile idiopathic arthritis

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • AI Symptom-Checker Could Help Emergency Doctors Prioritize Patients
  • 2 Minute Medicine: Pharma Roundup: Price Hikes, Breakthrough Approvals, Legal Showdowns, Biotech Expansion, and Europe’s Pricing Debate [May 12nd, 2025]
  • 2 Minute Medicine Rewind May 12, 2025
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Career
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
No Result
View All Result

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.