• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • Write for us
  • Contact us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Gastroenterology

Quick Take: Assessment of Trends in Transplantation of Liver Grafts From Older Donors and Outcomes in Recipients of Liver Grafts From Older Donors, 2003-2016

byConstance WuandAliya Ramjaun
February 24, 2019
in Gastroenterology, Surgery
Reading Time: 2 mins read
0
Share on FacebookShare on Twitter

RELATED REPORTS

Postoperative supplemental oxygen in liver transplantation not associated with reduced infection risk

Epstein-Barr viral load monitoring reduces risk of post-liver transplant lymphoproliferative disease

Study reports improvement in pediatric liver transplant outcomes over past decades

With an ever-increasing aging general population, older adults have the potential to contribute to an expansion of the donor pool. Organs from older donors are typically underused, despite the present shortage of donors. Historically, liver grafts from older donors have been associated with graft loss and increased recipient mortality, thus deterring their use. In this retrospective cohort study, outcomes of graft discard, graft loss and mortality were assessed in 4127 liver grafts from older donors and 3350 liver-only recipients of older donor grafts and compared to outcomes observed in 78,990 liver grafts from younger donors and 64,907 liver-only recipients of younger donor grafts. Researchers found that liver graft discard from older donors increased from 2003-2016, while mortality rates among recipients from both older and younger donors improved after liver transplant. When comparing mortality rates for recipients of grafts in 2003-2009 with recipients in 2010-2019, investigators found greater improvements in mortality occurring for recipients of grafts from older donors (p=0.04 for interaction). Recipients who received grafts from older donors in 2010-2016 had a 41% lower mortality risk than recipients in 2003-2009 (HR 0.59, 95% CI 0.52 to 0.68, p<0.001), while mortality among recipients of grafts from younger donors improved by 31% (HR 0.69, 95% CI 0.66 to 0.71, p<0.001). In terms of graft loss, graft loss for recipients of liver grafts improved in 2010-2016 compared to 2003-2009, with greater improvements for liver grafts from older donors. From 2010-2016, recipients of liver grafts from older donors had a 40% reduced risk of graft loss (HR 0.60, 95% CI 0.53 to 0.68, p<0.001), while recipients of grafts from younger donors had a 30% improvement of graft loss (HR 0.70, 95% CI 0.68 to 0.72, p<0.001). Taken together, the results from this study suggest that despite decreased use of liver grafts from older donors, there has been an overall improvement in all-cause graft loss and mortality among recipients of liver grafts from older donors. This study is limited in that it could not assess whether the improvement in outcomes correlated with improved post-transplant care or candidate selection for older donors.

Click to read the study in JAMA Surgery

Image: PD

©2019 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

Tags: cirrEnd-Stage Liver Disease (ESLD)liver transplant
Previous Post

Quick Take: Effects of a Thermal Accelerant Gel on Microwave Ablation Zone Volumes in Lung: A Porcine Study

Next Post

Parental nonmedical prescription opioid use linked to adolescent use

RelatedReports

Adaptive ventilation for central sleep apnea linked to increased mortality in heart failure patients
Gastroenterology

Postoperative supplemental oxygen in liver transplantation not associated with reduced infection risk

February 27, 2023
Resection of colorectal liver metastases may improve cost and longevity
Chronic Disease

Epstein-Barr viral load monitoring reduces risk of post-liver transplant lymphoproliferative disease

January 30, 2023
Chronic Disease

Study reports improvement in pediatric liver transplant outcomes over past decades

September 19, 2022
The ABCD2 score: Risk of stroke after Transient Ischemic Attack (TIA) [Classics Series]
Hematology/Oncology Classics

OPTN and UNOS update policy regarding hepatocellular carcinoma [Classics Series]

June 30, 2022
Next Post
Parental nonmedical prescription opioid use linked to adolescent use

Parental nonmedical prescription opioid use linked to adolescent use

Asymptomatic women at high risk for Multiple Sclerosis may have early subclinical neuroimaging abnormalities

Early intensive treatment of multiple sclerosis associated with slower progression of disability

Survival greater in cervical cancer patients undergoing abdominal hysterectomy compared to minimally invasive techniques: the LACC trial

Overlapping surgery not associated with adverse patient outcomes

License Our Award-Winning Physician-Written Medical News and Visual Abstracts

2 Minute Medicine is the leading authoritative medical news licensing service, and the only with reports written by practicing doctors.

LICENSE CONTENT

2MM+ Premium Access

No ads & unlimited access to all current reports, over 9000 searchable archived reports, visual abstracts, Weekly Rewinds, and the online edition of The Classics Series™ textbook.

Subscription Options
2 Minute Medicine

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Abnormal menstruation may be associated with worse cardiometabolic outcomes later in life
  • Past infection with pre-omicron variants of COVID-19 protects against re-infection
  • No difference in complete expulsion of intrauterine device between early and standard interval postpartum placement
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

Want more physician-written
medical news?

Join over 10 million yearly readers and numerous companies. For healthcare professionals
and the public.

Subscribe for free today!

Subscription options