• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • Write for us
  • Contact us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Obstetrics

Sentinel lymph node mapping identifies metastases in high-risk endometrial cancer

byDenise PongandLeah Hawkins Bressler, MD, MPH
January 3, 2016
in Obstetrics, Oncology
Reading Time: 3 mins read
0
Share on FacebookShare on Twitter

1. Among women undergoing pelvic and para-aortic lymphadenectomy, 10.6% had metastatic disease to the lymph nodes.

2. The sensitivity and specificity of sentinel lymph node (SLN) histology for metastatic disease confirmed on total lymphadenectomy were 100%.

Evidence Rating Level: 2 (Good)           

Study Rundown: Endometrial cancer is the most common gynecologic malignancy in the United States. At the time of diagnosis, most have disease confined to the uterus; a minority has spread to regional organs and lymph nodes, and an even smaller proportion has distant metastases. Current guidelines recommend surgical staging, but there is variation in evaluation of lymph node involvement across providers and institutions. Because prior studies have demonstrated that most women with early stage endometrial cancer have negative pelvic lymph nodes, total lymphadenectomy is not standardly performed. However, sometimes the surgical stage can be underestimated intraoperatively and women who may have lymph node metastases do not receive lymphadenectomy. SLN mapping, which is used in management of breast cancer and melanoma, has been performed in women with endometrial cancer at low risk for nodal involvement. In the present work, the authors studied the use of SLN mapping in women at high risk of nodal involvement.

Results demonstrate a high detection rate with SLN mapping such that in women who met criteria for bilateral pelvic and periaortic lymphadenectomy (PPALAN), 10.6% had lymph node metastases. Strengths included prospective data collection and use of PPALAN to evaluate the test characteristics of SLN mapping in this setting. The study was limited by small sample size, lack of a comparison group and selection bias, since the characteristics of participants who declined were not studied. Randomized trials including a control arm are needed to better understand the role for SLN mapping in high risk cases of endometrial cancer.

Click to read the study in AJOG

Relevant Reading: Prospective assessment of lymphatic dissemination in endometrial cancer: a paradigm shift in surgical staging

RELATED REPORTS

#VisualAbstract: Tamoxifen increases the risk of endometrial cancer in premenopausal women with breast cancer

Letrozole and abemaciclib in estrogen receptor–positive recurrent endometrial cancer

Endovaginal ultrasound highly sensitive screen for endometrial cancer [Classics Series]

In-Depth [prospective cohort]: This study assessed the use of SLN mapping during robotic tumor staging surgery among women with biopsy-proven endometrial cancer (n = 123), including those at high risk for nodal metastasis (n = 85) who underwent planned pelvic and para-aortic (total) lymphadenectomy. The primary outcome of interest was the feasibility of SLN mapping. Secondary outcomes included the sensitivity and specificity of SLN mapping, using total lymphadenectomy as the gold standard.

Bilateral pelvic and para-aortic lymph nodes were mapped in 80% of patients. At least one sentinel lymph node was detected in 97% of participants. Among patients at high risk for nodal metastases who underwent both pelvic and para-aortic lymphadenectomy, 10.6% were found to have lymph node metastases and in 44% of these, the SLN was the only positive node. There were cases in which final SLN pathology was negative but metastatic disease was discovered on completion lymphadenectomy. The sensitivity and specificity of SLN histology for metastatic disease on pelvic and para-aortic lymphadenectomy were both 100%.

Image: CC/Wiki/EdUthman

©2015 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

Tags: endometrial cancersentinal lymph node biopsy
Previous Post

History of maternal anorexia linked to small infant size

Next Post

Endovascular interventions appear superior to surgery in treatment of blister-like aneurysms

RelatedReports

#VisualAbstract: Tamoxifen increases the risk of endometrial cancer in premenopausal women with breast cancer
StudyGraphics

#VisualAbstract: Tamoxifen increases the risk of endometrial cancer in premenopausal women with breast cancer

January 24, 2023
Recurrence of endometrial hyperplasia following medical therapy is common
Oncology

Letrozole and abemaciclib in estrogen receptor–positive recurrent endometrial cancer

December 28, 2022
The ABCD2 score: Risk of stroke after Transient Ischemic Attack (TIA) [Classics Series]
Chronic Disease

Endovaginal ultrasound highly sensitive screen for endometrial cancer [Classics Series]

August 9, 2022
Recurrence of endometrial hyperplasia following medical therapy is common
Oncology

Lenvatinib plus pembrolizumab increased survival for advanced endometrial cancer patients when compared to chemotherapy

March 27, 2022
Next Post
Clinical decision rule highly sensitive in predicting subarachnoid hemorrhage

Endovascular interventions appear superior to surgery in treatment of blister-like aneurysms

Vitamin D supplementation amongst post-menopausal women did not improve functional outcomes

Osteoporosis may be over-treated with non-diagnostic DEXA scan results

Radiation dose associated with increased heart disease in Hodgkin lymphoma survivors

Substantial cardiovascular disease among pediatric cancer survivors

License Our Award-Winning Physician-Written Medical News and Visual Abstracts

2 Minute Medicine is the leading authoritative medical news licensing service, and the only with reports written by practicing doctors.

LICENSE CONTENT

2MM+ Premium Access

No ads & unlimited access to all current reports, over 9000 searchable archived reports, visual abstracts, Weekly Rewinds, and the online edition of The Classics Series™ textbook.

Subscription Options
2 Minute Medicine

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Specific histopathologic renal lesions may be associated with increased risk of cardiovascular disease
  • Symptom and viral relapse more common in COVID-19 patients without antiviral treatment
  • The Scan by 2 Minute Medicine®: Endometriosis Awareness Month, OnlineMedEd Charges, Canadian Grocery Store Controversy, BetterHelp’s Privacy Concerns
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

Want more physician-written
medical news?

Join over 10 million yearly readers and numerous companies. For healthcare professionals
and the public.

Subscribe for free today!

Subscription options