Tag: adverse events

1. Across 26 cancer clinical trials, researchers detected fewer baseline symptoms than those reported by patients, suggesting that adjustments to baseline determinations in clinical trials should consider patient reports as reliable data points. Evidence Rating Level: 2 (Good) Baseline symptoms are an important consideration in oncologic clinical trials. Currently, the standard...
1. In this large, retrospective cohort study of veteran’s health administration (VHA) hospitals, males admitted to the hospital for non-cardiac reasons who had an intensification of their antihypertensive regimen before discharge had an increased risk of readmission and serious adverse events. 2. There was no difference in cardiac events or...
Immune-checkpoint inhibitors (ICIs) have significantly improved outcomes in a variety of malignancies. Immune-related adverse events, however, are common and may lead to treatment discontinuation and adverse events. Immune-related cutaneous adverse events (ircAEs) are the most frequent and earliest to develop, but there is no evidence-based consensus regarding the management...
1. Patients with a higher disease burden of acute lymphoblastic leukemia (ALL) treated with CD19-specific chimeric antigen receptor (CAR) T cell therapy experienced greater incidences of cytotoxic release syndrome and neurotoxicity compared to low disease burden patients. 2. Patients with high disease burden had shorter overall survival times compared to...
1. The American Academy of Pediatrics (AAP) policy statement on disclosure of adverse events recommends the formulation of institutional policies surrounding disclosure, education, and emotional support for physicians. Statement Rundown: There has been an increased focus on patient safety by physicians and patient families in the last decade. Studies have...
Image: PD 1. Drug-related complications were the most common type of adverse event in hospitalized patients. 2. Adverse events due to negligence in hospitalized patients were more likely to cause serious disability or death than adverse events not attributed to negligence. Study Rundown: Many adverse events in hospitalized patients are not preventable due...