Tag: anesthesia

Protective intraoperative mechanical ventilation has been associated with reduced postoperative pulmonary complication risk. Obesity is associated with an increased risk of atelectasis and impaired respiratory function. In this setting, high positive end-expiratory pressure with alveolar recruitment maneuvers have been proposed for routine intraoperative mechanical ventilation to prevent these physiologic...
1. In this randomized controlled trial, EEG-guided anesthetic administration during surgical interventions did not reduce the incidence of delirium compared to anesthetic administration as usual in elderly patients. 2. There was a small reduction in 30-day mortality in patients who received EEG-guided anesthetic administration Evidence Rating Level: 1 (Excellent) Study Rundown: EEG-guided...
Emergence agitation, characterized by confusion, disorientation, crying, moaning, shouting, or screaming after general anesthesia, can lead to serious adverse events including increased injury, pain, hemorrhage, and self-extubation. Some studies have suggested that the use of volatile anesthetic agents is associated with an increased risk of emergence agitation. In this...
Effect of Lanadelumab Compared With Placebo on Prevention of Hereditary Angioedema Attacks: A Randomized Clinical Trial Hereditary angioedema with C1 inhibitor deficiency is a rare autosomal dominant disorder characterized by C1 inhibitor deficiency (type I) or dysfunction (type II) causing dysregulated plasma kallikrein activity, and in turn, life-threatening recurrent angioedema...
1. In this sibling matched cohort study, IQ scores in adolescence were comparable between infants exposed to general anesthesia before age 3 and unexposed siblings. 2. Secondary outcomes of cognition were also similar between these two groups. Evidence Rating Level: 2 (Good) Study Rundown: The central nervous system develops markedly throughout infancy,...
1. Patients undergoing general anesthesia for endovascular treatment of acute stroke had increased odds of death and respiratory complications, and decreased odds of recanalization and good functional outcome as compared to those undergoing conscious sedation. Evidence Rating Level: 1 (Excellent) Study Rundown: While recent trials have demonstrated the value of rapid...
In this section, we highlight the key high-impact studies, updates, and analyses published in medicine during the past week. Long-Term Efficacy of a Hepatitis E Vaccine Hepatitis E virus (HEV) is most frequently a waterborne infection in resource-limited countries that can result in acute hepatitis and death especially in pregnant women....
1. Continuous postoperative levobupivacaine infusion into the surgical site was associated with less pain and decreased consumption of analgesics following modified radical mastectomy. 2. Patients in the levobupivacaine group reported high levels of satisfaction with no change in rates of nausea and vomiting. Evidence Rating Level: 1 (Excellent) Study Rundown: The use...
Image: PD 1. Preoperative in-room delay (known as anesthesia ready time or ART) of greater than 1 hour was an independent risk factor for surgical site infection (SSI) in spine surgery.  2. Anterior approach, ASA class, number of operated levels, trauma or tumor, and length of case were all predictive of...