Tag: anesthesia

1. Among patients undergoing ambulatory orthopedic surgical procedures, percutaneous peripheral nerve stimulation reduced pain and the use of opiates in the first 7 postoperative days. Evidence Level Rating: 1 (Excellent) Poor pain control following surgery is very common and is associated with excessive reliance on opiates for analgesia. Percutaneous peripheral nerve...
1. In patients undergoing open ventral hernia repair with mesh placement, liposomal bupivacaine transversus abdominus plane block did not reduce postoperative opioid use when compared with simple bupivacaine and a placebo. Evidence Rating Level: 1 (Excellent) Study Rundown: Multiple pain control strategies that do not rely on opioids have been developed...
1. Among patients undergoing lower limb revascularization, the use of neuraxial compared with general anesthesia was associated with decreased 30-day all-cause mortality. Evidence Rating Level: 2 (Good) Although endovascular interventions are increasingly common for the surgical management of peripheral artery disease, lower limb revascularization surgeries like endarterectomy and arterial bypass are...
1. A decision aid tool significantly helped resolve decision conflict in patients contemplating the use of epidural anesthesia during labour. Evidence Rating Level: 1 (Excellent) In Japan, analgesic use in delivery of babies is low compared to other countries, with only 6.2% of women receiving epidural anesthesia in 2016. This could...
Advance care planning in patients with advanced cancer: A 6-country, cluster-randomised clinical trial 1. An advanced care planning (ACP) intervention was not found to increase quality of life compared to usual care, in patients with advanced lung or colorectal cancer. 2. ACP was found to increase the number of patients receiving...
Protective intraoperative mechanical ventilation has been associated with reduced postoperative pulmonary complication risk. Obesity is associated with an increased risk of atelectasis and impaired respiratory function. In this setting, high positive end-expiratory pressure with alveolar recruitment maneuvers have been proposed for routine intraoperative mechanical ventilation to prevent these physiologic...
1. In this randomized controlled trial, EEG-guided anesthetic administration during surgical interventions did not reduce the incidence of delirium compared to anesthetic administration as usual in elderly patients. 2. There was a small reduction in 30-day mortality in patients who received EEG-guided anesthetic administration Evidence Rating Level: 1 (Excellent) Study Rundown: EEG-guided...
Emergence agitation, characterized by confusion, disorientation, crying, moaning, shouting, or screaming after general anesthesia, can lead to serious adverse events including increased injury, pain, hemorrhage, and self-extubation. Some studies have suggested that the use of volatile anesthetic agents is associated with an increased risk of emergence agitation. In this...
Effect of Lanadelumab Compared With Placebo on Prevention of Hereditary Angioedema Attacks: A Randomized Clinical Trial Hereditary angioedema with C1 inhibitor deficiency is a rare autosomal dominant disorder characterized by C1 inhibitor deficiency (type I) or dysfunction (type II) causing dysregulated plasma kallikrein activity, and in turn, life-threatening recurrent angioedema...
1. In this sibling matched cohort study, IQ scores in adolescence were comparable between infants exposed to general anesthesia before age 3 and unexposed siblings. 2. Secondary outcomes of cognition were also similar between these two groups. Evidence Rating Level: 2 (Good) Study Rundown: The central nervous system develops markedly throughout infancy,...