Tag: asthma

1. When compared with overweight and non-severe obesity among adolescents, severe obesity was associated with higher rates of eating when bored, decreased participation in sports and activities, and higher levels of stress. 2. Median hs-CRP, as well as prevalence of asthma, depression, and obstructive sleep apnea were elevated among adolescents...
1. This 6-year follow up of the Vitamin D Antenatal Asthma Reduction Trial found no significant difference in the incidence of asthma or recurrent wheeze between children whose mothers received daily vitamin D versus placebo. This result contrasts with the between-group difference detected at early time points in the...
1. Commonly prescribed antibiotics in infancy are associated with later diagnosis of allergic disease in childhood Evidence Rating Level: 2 (Good) The use of antibiotics negatively impacts the human microbiome, decreasing bacterial diversity. These kinds of changes to the microbiome have been previously found to be associated with allergic disease. In...
Maintenance inhaled corticosteroid therapy is effective for preventing severe asthma exacerbations in patients with mild to moderate asthma at baseline. However, adherence to these agents in clinical practice is poor. A proposed alternative approach is to use a combination of a long-acting beta-agonist (LABA), such as formoterol, and an...
1. In this cross sectional study, children with asthma living in dangerous neighborhoods were less likely to have asthma symptoms if they had strong family relationships. 2. Greater neighborhood danger was associated with increased asthma-related activity limitations, larger Th2 cytokine response, and less sensitivity to glucocorticoids. Evidence Rating Level: 3 (Average) Study...
1. In this retrospective cohort study looking at patients admitted with asthma exacerbations and treated with corticosteroids, antibiotic administration within the first two days, given for at least two days, was associated with longer length of stay in hospital and higher health care expenditures. 2. There was no concurrent improvement...
1. One-tenth of new diagnoses of pediatric asthma could potentially be avoided with the elimination of childhood obesity. Evidence Rating Level: 2 (Good) Study Rundown: Despite increased efforts to prevent and reduce obesity, rates of childhood obesity continue to increase, with almost 20% of children in the United States meeting obesity...
1. In a case-report, 41-year-old patient requiring intubation for respiratory failure due to status asthmaticus clinically improved after administration of omalizumab (XOLAIR®). 2. The findings of this study suggested that omalizumab, a medication used for IgE-mediated moderate to severe asthma, could be a new rescue treatment option for patients unresponsive...
1. Glucocorticoid dependent severe asthmatics treated with dupilumab for 24 weeks used significantly lower doses of glucocorticoids while maintaining asthmatic control compared to placebo treated patients. 2. Dupilumab treated patients experienced lower rates of severe asthma exacerbations compared to those treated with placebo. Evidence Rating Level: 1 (Excellent)      Study Rundown: Patients with...
1. Identified viral pathogens were not associated with asthma exacerbation severity, but were linked to increased treatment failure. Evidence Rating Level: 2 (Good) Study Rundown: Viral and bacterial pathogens are known to be common triggers for asthma exacerbation. There is limited research evaluating the effect of specific viral pathogens on asthma...