Tag: bisphosphonates

1. Bisphosphonates and denosumab increased bone mineral density (BMD) in men receiving androgen deprivation therapy (ADT) for nonmetastatic prostate cancer, with denosumab also showing some evidence of vertebral fracture reduction. 2. Three trials for lifestyle intervention showed no statistically significant difference in BMD compared to exercise and standard care. Evidence Rating...
1. In a prospective cohort study of over 89 000 postmenopausal women, the use of bisphosphonates for osteoporosis was associated with a significant reduction in the risk of endometrial cancer. Evidence Rating Level: 3 (Average) Study Rundown: Although oral bisphosphonates are most commonly used for the treatment of osteoporosis among post-menopausal...
1. A single dose of zoledronic acid improved bone mineral density over 2 years in frail elderly women. 2. Rates of fracture or mortality did not differ significantly between zoledronic acid treatment and placebo groups. Evidence Rating Level: 1 (Excellent) Study Rundown: Although as many as 85% of frail elderly adults living...
1. This systematic review demonstrated that in postmenopausal women with osteoporosis, bisphosphonates, denosumab and teriparatide were associated with a significantly reduced risk of vertebral and nonvertebral fractures, compared to placebo. 2. The comparative effectiveness of the different pharmacological agents available to treat osteoporosis is unclear. Evidence Rating Level: 1 (Excellent)...