Tag: chagas disease

Treatment of adult chronic indeterminate Chagas disease with benznidazole and three E1224 dosing regimens: a proof-of-concept, randomised, placebo-controlled trial Chagas disease is a major endemic vector-borne disease and global health issue. Currently, there is a paucity of new treatments for Chagas disease, as benznidazole and nifurtimox continue to be the...
Image: PD In this section, we highlight the key high-impact studies, updates, and analyses published in medicine during the past week. Pharmacotherapy for Adults With Alcohol Use Disorders in Outpatient Settings Despite continued high rates of morbidity and early mortality caused by alcohol use disorders (AUDs), less than 10% of patients with...
Image: PD  1. Posaconazole showed anti-trypanosomal activity, but there was a high rate of treatment failure 10 months after treatment.  2. Posaconazole had fewer serious adverse events than benznidazole.  Evidence Rating Level: 1 (Excellent)  Study Rundown: Chagas disease is caused by the parasite Trypanosoma cruzi which in its chronic form leads to cardiac...