Trials demonstrate effective antibody-based treatment for psoriasis: AMAGINE-2 and 3 Study
1. Brodalumab was more effective than either placebo or ustekinumab at reducing the severity of psoriasis after 12 weeks of...
Enzyme replacement therapy shows promise for rare lysosomal storage disease: The ARISE study
1. Sebelipase alfa treatment significantly improved liver function tests among 31% of patients with lysosomal acid lipase deficiency receiving the drug...
No change in perinatal outcomes with fetal electrocardiogram
1. Deliveries using fetal electrocardiogram (ECG) did not differ from those using fetal heart-rate monitoring alone when looking at...
Designer molecule targets key protein in tenosynovial giant-cell tumor
1. PLX3397 is a targeted inhibitor of the CSF1 receptor that produced a partial response in about half of study...
Promising phase 2 results for new plaque psoriasis therapy
1. Guselkumab, an anti-interleukin-23 antibody, produced better responses in patients with moderate to severe plaque psoriasis than standard anti-TNF alpha...
![siRNA against antithrombin alleviates symptoms of hemophilia [PreClinical]](https://2minutemedicine-wpengine.netdna-ssl.com/wp-content/uploads/2015/04/clot-CCWiki-350x250.jpg)
CT screen ineffective for detecting cancer in patients with blood clots [SOME Trial]
1. There was no clinical benefit from the addition of CT imaging to a cancer screening strategy for patients with...
New gene linked to male infertility
1. Mutations in TEX11 were found in 2.4% of infertile men with non-obstructive azoospermia without another known cause. Evidence Rating...
STOP-IT trial supports fixed-duration antibiotic therapy for intraabdominal infections
1. Rates of surgical site infection, recurrent intraabdominal infection, or death within 30 days were similar in patients with intraabdominal...
Study finds variation in treatment of extremely pre-term infants among hospitals
1. There was variation in how aggressively hospitals treat infants born before 27 weeks gestation. 2. The variation in treatment...
![PET scans in early-stage Hodgkin’s lymphoma may help guide therapy [RAPID trial]](https://2minutemedicine-wpengine.netdna-ssl.com/wp-content/uploads/2015/04/1280px-Hodgkin_lymphoma_cytology_large-350x250.jpg)
PET scans in early-stage Hodgkin’s lymphoma may help guide therapy [RAPID trial]
1. In patients with negative PET scans after 3 cycles of chemotherapy, 3-year progression free survival was slightly better among...
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