Tag: chemotherapy

1. Enzalutamide along with androgen-deprivation therapy was shown to significantly increase median overall survival among men with non-metastatic, castration-resistant prostate cancer. 2. Adverse events for enzalutamide and androgen-deprivation therapy were shown to be consistent with the established safety profile of enzalutamide. Evidence Rating Level: 1 (Excellent) Study Rundown: Enzalutamide is an approved therapy for...

1. In children with neutropenia and chemotherapy for cancer, 39·0°C ear temperature as a threshold for fever is non-inferior to 38·5°C for safety and appeared efficacious. Evidence Rating Level: 1 (Excellent) Febrile neutropenia is the most frequent complication of chemotherapy. Currently, the temperature limit defined for children varies across different...

1. Enzalutamide along with androgen-deprivation therapy was shown to significantly increase median overall survival among men with non-metastatic, castration-resistant prostate cancer. 2. Adverse events for enzalutamide and androgen-deprivation therapy were shown to be consistent with the established safety profile of enzalutamide. Evidence Rating Level: 1 (Excellent) Study Rundown: Enzalutamide is an approved...

Association of prehospital plasma transfusion with survival in trauma patients with hemorrhagic shock when transport times are longer than 20 minutes: A post-hoc analysis of the PAMPer and COMBAT clinical trials 1. Prehospital plasma transfusion is associated with increased survival in the setting of hemorrhagic shock, particularly with longer transport...

1.  Chemotherapy and/or radiotherapy may provoke significant declines in CD4 counts in HIV patients as compared to other treatments, which in turn are associated with increased mortality. Evidence Rating Level: 2 (Good) Treating cancer in patients with human immunodeficiency virus (HIV) infection can be problematic due to the immunosuppressive effects of certain...

1. Patients undergoing laparoscopic distal gastrectomy for locally advanced gastric cancer have better postoperative outcomes when compared to those undergoing traditional open distal gastrectomy. Evidence Rating Level: 1 (Excellent) The use of multiple treatment modalities, including surgery, forms the current standard of care in the management of locally advanced gastric cancer....

Screening for breech presentation using universal late-pregnancy ultrasonography: A prospective cohort study and cost effectiveness analysis Fetal presentation has long been determined by way of clinical examination only, despite the relative ease with which breech presentation can be identified through ultrasound screening. As such, many women continue to present in...

1. In a mouse model of breast cancer, treatment with the chemotherapy paclitaxel (Ptx) enhanced tumor cell dissemination and the formation of micrometastatic lung lesions. 2. Prophylactic treatment with rebastinib diminished Ptx-driven metastatic progression by reducing levels of circulating tumor cells (CTCs) in the blood. Evidence Rating Level: 2 (Good) Study...

1. Patients with recurrent urothelial carcinoma experienced significantly longer median survival times when treated with pembrolizumab compared with chemotherapy agents.   2. Fewer treatment-related adverse events were observed by the pembrolizumab group compared to the chemotherapy group. Evidence Rating: 1 (Excellent) Study Rundown: Metastatic urothelial carcinoma is a difficult condition to treat. First-line...

1. Less hair loss was observed in women who received scalp cooling prior to the start of adjuvant chemotherapy for early-stage breast cancer. 2. Improved quality of life measures were observed with the use of this scalp cooling device. Evidence Rating Level: 2 (Good) Study Rundown: Hair loss remains one of the...