Tag: chemotherapy

Image: PD 1. Adding angiogenesis-targeted sunitinib therapy to prednisone in the treatment of metastatic castration-resistant prostate cancer (mCRPC) does significantly improves progression-free survival, but not overall survival. 2. The potential uses of anti-angiogenic therapy in this setting requires further investigation. Evidence rating level: 1 (Excellent) Study Rundown: The standard approach to managing metastatic,...
Image: PD  1.  Patients diagnosed with stage III or IV melanoma are at risk for the development of further primary melanomas, particularly if they have a history of multiple primary melanomas prior to their diagnosis.  Evidence rating level: 2 (Good) Study Rundown: In recent year, B-raf inhibitors such as Vemurafenib have been...
Image: PD  Oxaliplatin 1. The 12-gene Recurrence Score can predict recurrence risk and disease-free survival in both stage II and III colon cancer. 2. Higher scores may help predict absolute benefit of oxaliplatin for stage II and IIIA/B disease. Evidence rating level:  2 (Good) Study Rundown: Given the complex treatment options available for...
Image: PD 1. Dose-dense (DD) Temozolomide does not improve overall survival or progression-free survival in newly diagnosed glioblastoma. 2. O6methylguanine-DNA methyltransferase (MGMT) methylation status is predictive for treatment response. Evidence rating level: 1 (Excellent) Study rundown: Glioblastomas are malignancies of the central nervous system with extremely poor prognosis and median survival times of...
Image: PD 1. DA-EPOCH-R therapy achieved high rates of remission without radiotherapy.  2. Patients receiving DA-EPOCH-R therapy maintained normal cardiac ejection fractions up to 10 years after treatment.  Evidence Rating Level: 2  Study Rundown: Subject to the limitations of a phase-II clinical trial, this study demonstrates that DA-EPOCH-R (dose-adjusted etoposide, doxorubicin, and cyclophosphamide...
Image: PD 1. Painful peripheral neuropathy is a common side effect of modern chemotherapy regimens. 2. The serotonin and norepinephrine reuptake inhibitor duloxetine significantly reduces neuropathic pain and improves quality of life in patients receiving chemotherapy.  Study Rundown: Peripheral neuropathy is a common side effect of chemotherapy that has proven extremely difficult...