Tag: chronic kidney disease (CKD)
1. Vadadustat was shown to be non-inferior to darbepoetin alfa in cardiovascular safety for patients with anemia and dialysis-dependent chronic kidney disease (DD-CKD).
2. Vadadustat was shown to present comparable efficacy in normalizing hemoglobin concentration compared to darbepoetin alfa in the patient population.
Evidence Rating Level: 1 (Excellent)
Study Rundown: Chronic kidney...
1. Stopping renin-angiotensin system inhibition in patients with advanced chronic kidney disease was associated with higher risk of mortality, major cardiovascular events, and lower risk of kidney replacement therapy.
Evidence Rating Level: 2 (Good)
Studies have shown that renin-angiotensin system inhibitors (RASi) are effective in delaying chronic kidney disease (CKD) progression. Angiotensin-converting enzyme...
1. Among patients with severe chronic kidney disease requiring an arteriovenous fistula for hemodialysis, abnormal digital-brachial index was found to be predictive of fistula patency.
Evidence Level Rating: 2 (Good)
Some patients with advanced chronic kidney disease (CKD) may require renal replacement therapies like hemodialysis (HD), at which point creation and...
1. Oxygenated hypothermic machine perfusion (HMPO2) of kidneys donated after circulatory death was associated with fewer severe complications and lower rates of graft failure compared to hypothermic machine perfusion without oxygenation (HMP).
2. There was no significant difference in mean eGFR between HMPO2 and HMP despite potential beneficial effects suggested...
1. Finerenone treatment lowered the risk of chronic kidney disease (CKD) progression in patients diagnosed with type 2 diabetes and advanced CKD.
2. Treatment with finerenone also lowered the risk of cardiovascular events in patients diagnosed with type 2 diabetes and advanced CKD.
Evidence Rating Level: 1 (Excellent)
Study Rundown: The leading...
1. Bariatric surgery for patients with obesity and end-stage kidney disease was associated with lower all-cause mortality at 5 years.
Evidence Rating: 2 (Good)
Obesity and end-stage kidney disease are significant causes of mortality and morbidity in North America, and represents a significant burden to the healthcare system. Bariatric Surgery...
Chronic kidney disease (CKD)-related anemia is associated with significant morbidity, and remains undertreated worldwide. Adequate treatment of CKD-related anemia is associated with reduced transfusion rates and improved clinical outcomes. Roxadustat is a hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitor that stabilizes HIF-alpha subunits, resulting in increased transcriptional activity and functional...
1. In this cross sectional study of older adults (>65 years) who had undergone gold-standard glomerular filtration rate (GFR) measurement with inulin excretion, different methods of estimating GFR demonstrated variation in bias and accuracy.
2. Despite the observed differences in bias and accuracy in this study population, differences were not...
Chronic metabolic acidosis is often seen in patients with chronic kidney disease (CKD), and results from an inability to excrete metabolically produced acid. This, in turn, is associated with bone resorption, muscle catabolism, and progression of kidney disease. Veverimer is a non-absorbable medication that removes hydrochloric acid from the...