Tag: chronic obstructive pulmonary disease (COPD)

1. Triple therapy for severe chronic obstructive pulmonary disease (COPD) with budesonide-glycopyrrolate-formoterol was associated with significantly lower risk of COPD exacerbation compared to dual therapy groups. Evidence Rating Level: 1 (Excellent) Study Rundown: Treatment for COPD involves a stepwise approach where treatments are added when necessary to control symptoms and reduce exacerbations....
1. In this double-blind randomized trial of COPD patients without previous indication for beta blocker therapy, treatment with extended-release beta-blockers failed to generate improved health outcomes versus placebo. No significant between-group difference was found in the median time until the first exacerbation of COPD. 2. Patients in the metoprolol group...
1. In this double-blind randomized trial of COPD patients without previous indication for beta blocker therapy, treatment with extended-release beta-blockers failed to generate improved health outcomes versus placebo. No significant between-group difference was found in the median time until the first exacerbation of COPD. 2. Patients in the metoprolol group...
1. In this retrospective cohort study, an FEV1:FVC threshold of 0.71 was the best fit for discriminating COPD-related events, though it was not statistically different than using 0.70. 2. The FEV1:FVC 0.70 threshold provided optimal discrimination in a subgroup analysis of ever smokers and in adjusted models. Evidence Rating Level: 2...
1. Two complementary phase 3 clinical trials randomized patients with moderate-to-severe COPD to receive either benralizumab or a placebo and found that the trial agent did not lead to a significant reduction in chronic obstructive pulmonary disease (COPD) exacerbation rates. 2. Safety outcomes were comparable between groups. Evidence Rating Level:...
Corticosteroids are frequently used in the treatment of acute chronic obstructive pulmonary disease (COPD) exacerbations. However, the use of systemic corticosteroids is not without its risks. As such, strategies to limit systemic corticosteroid exposure are needed. In this multicenter randomized controlled trial, 318 patients age 40 years and older...
Association between incidence exposure to benzodiazepines in early pregnancy and risk of spontaneous abortion Previous studies have shown that benzodiazepine use in early pregnancy is associated with spontaneous abortion (SA). The association between specific benzodiazepines and the risk of SA, however, has not been investigated. In this nested case-control study...