Tag: covid

1. Levels of antibodies against the trimeric spike protein and receptor-binding domain were 36- and 77-fold higher in the BNT162b2 group compared to control. 2. There were no vaccine-related serious adverse events. Evidence Rating Level: 1 (Excellent)  Study Rundown: Current research on COVID-19 vaccination has revolved around a homologous dosing schedule (administering...
1. After receiving the BNT162b2 SARS-CoV-2 vaccine, fewer cancer patients demonstrated seropositivity for COVID antibodies compared to age-matched healthy controls, but those that were seropositive had comparable titers to healthy controls. 2. The COVID vaccine was found to have an acceptable safety profile amongst cancer patients currently on treatment, with...
1. Retrospective analysis of hospital records showed decreased hospital admission rates for non-COVID-19 diseases in Denmark since the first lockdown. 2. Mortality rates were also shown to be higher for non-COVID-19 diseases, including respiratory diseases, cancer, pneumonia, and sepsis. Evidence Rating Level: 2 (Good) Study Rundown: The COVID-19 pandemic has put a...
1. This cross-sectional study found that events leading to informal social gatherings, such as birthdays among households, were associated with increased rates of diagnosed COVID-19 infection. 2. COVID-19 diagnoses per 10,000 individuals were higher among child birthdays than adult birthdays, further highlighting informal social gatherings as a potential important source...
1. Therapeutic anticoagulation with rivaroxaban or enoxaparin did not improve clinical outcomes and increased bleeding compared with prophylactic anticoagulation. 2. Net clinical benefit composite of death, thrombotic events, and major or clinically relevant non-major bleeding was not significantly different between groups. Evidence Rating Level: 1 (Excellent) Study Rundown: COVID-19 is associated with...
1. In this epidemiological cohort study based out of Valencia, Spain, the neighborhood where the hospital and COVID-19 testing facility was situated correlated with a high number of total infectious connections and was potentially a major contributor to local spread. 2. These findings suggest that a more selective and strategic...
1. A similar proportion of patients died within 28 days of randomization in both groups (high-titre convalescent plasma vs. usual care). 2. Allocation to convalescent plasma had no significant effect on the proportion of patients discharged from hospital within 28 days. Evidence Rating Level: 1 (Excellent) Study Rundown: Convalescent plasma is a...
1. In-hospital mortality within 30 days of admission for COVID-19 was 48% (vs. global mortality 31.5%). 2. Increased age, underlying comorbidities and delay in admission were associated with an increased mortality rate among African patients. Evidence Rating Level: 2 (Good) Study Rundown: The COVID-19 pandemic has exposed long-standing inequities in healthcare. Critically...
1. There was a vaccine efficacy of 97.2% against symptomatic COVID-19 infection in individuals at least 7 days after their second vaccine dose. 2. Substantial and consistent declines in COVID-19 incidence corresponded to greater vaccine coverage. Evidence Rating Level: 2 (Good) Study Rundown: Beyond clinical trials, there is growing evidence of the...